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TranscriptomicsCtnnb1-targeted genes in mouse post-meiotic germ cells
To determine differential gene expression in Ctnnb1 CKO mice testis compared to CTRL mice testis. The Agilent Mouse Whole Genome 4x44K array (Samples are from pooled total testes RNA from 4 CTRL and 4 Ctnnb1 CKO mice; dye-swap was performed.)
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-30773 | biostudies-arrayexpress
TranscriptomicsCharacterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.
Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alter...
ORGANISM(S): Homo sapiens 
2011-04-09 | E-GEOD-28476 | biostudies-arrayexpress
TranscriptomicsTranscriptomic characterization of Hepatocellular Carcinoma with CTNNB1 mutation
We report transcritomic characterization of changes in CTNNB1 mutation positive HCCs in comparison to paratumoral tissues 4 pair of HCC and paratumoral liver tissues are sequenced and compared
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-55048 | biostudies-arrayexpress
TranscriptomicsEither Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis
Stable activation of the WNT signaling effector beta-catenin (CTNNB1(ex3) in ovarian granulosa cells results in the formation of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life. Loss of the tumor suppressor gene Pten accelerates GCT formation in the CT...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-27656 | biostudies-arrayexpress
ProteomicsUSP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination
Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy driven by genetic and epigenetic alterations, where super-enhancers (SEs) play key oncogenic roles, representing promising therapeutic targets in AML. Through H3K27ac ChIP-seq profiling of 7 AML cell lines and 13 primary samples,...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD066445 | Pride
Usp20  super-enhancer  aml  ctnnb1  as1517499 
UnknownClinical phenotypic spectrum of CTNNB1 neurodevelopmental disorder.
Not available
S-EPMC11872165 | biostudies-literature
TranscriptomicsSeminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in sertoli cells
To elucidate the role(s) of WNT/CTNNB1 signaling in the testis, transgenic Ctnnb1 tm1Mmt/+;Amhr2 tm3(cre)Bhr/+ mice were generated to obtain sustained activation of the WNT/CTNNB1 pathway in Sertoli cells. Male Ctnnb1 tm1Mmt/+;Amhr2 tm3(cre)Bhr/+ mice were sterile because of testicular atrophy start...
ORGANISM(S): Mus musculus 
2011-04-05 | E-GEOD-28402 | biostudies-arrayexpress
GenomicsQuantitative Analysis of Wild Type,Ctnnb1 deltaEx3 and Ctnnb1 deltaEx2-6 Spinal Cord Transcriptomes
Quantitative Analysis of Wild Type,Ctnnb1 deltaEx3 and Ctnnb1 deltaEx2-6 Spinal Cord Transcriptomes
PRJNA488003 | ENA
ProteomicsThe proteomic landscape of CTNNB1 mutated low-grade early-stage endometrial carcinomas
Endometrial carcinoma is the most frequent gynecologic malignancy in western countries. In recent years, mutations in CTNNB1 have been associated with worse prognosis in low-risk carcinomas. However, there is a lack of understanding of the proteomic implications of CTNNB1 mutations in this type of t...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD068004 | Pride
Proteomics  endometrial carcinoma  wnt pathway  immune microenvironment 
TranscriptomicsTranscription profiling of human WT1-mutant versus WT1 wild-type Wilms tumors
Gain-of-function mutations in exon 3 of beta-catenin (CTNNB1) are specific for Wilms' tumors that have lost WT1, but 50% of WT1-mutant cases lack such "hot spot" mutations. To ask whether stabilization of beta-catenin might be essential after WT1 loss, and to identify downstream target genes, we com...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6120 | biostudies-arrayexpress
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