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ProteomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
Qualitative analysis of proteome is to study the types and quantities of proteome identified by samples under different conditions, and to perform functional analysis of the identified proteins, so as to provide reference information for quantitative and modification analysis of high-throughput prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD053080 | Pride
Usp20 Hif1a 
ProteomicsTargeted protein of USP20 by LC-MS/MS in HepG2 cells
Obesity is a metabolic disease accompanied by lipid metabolism that can cause hyperlipidemia, non-alcoholic fatty liver disease, and artery atherosclerosis. Sleeve gastrectomy (SG) is a type of bariatric surgery that can effectively treat obesity and improve lipid metabolism. However, its specific u...
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD037693 | Pride
Hepg2 Lc-ms/ms Usp20 
GenomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
USP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
PRJNA1110766 | ENA
ProteomicsUSP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination
Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy driven by genetic and epigenetic alterations, where super-enhancers (SEs) play key oncogenic roles, representing promising therapeutic targets in AML. Through H3K27ac ChIP-seq profiling of 7 AML cell lines and 13 primary samples,...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD066445 | Pride
Usp20  super-enhancer  aml  ctnnb1  as1517499 
GenomicsDeubiquitinase USP20 promotes breast cancer metastasis by stabilizing SLUG
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SLUG
PRJNA438964 | ENA
TranscriptomicsUSP20 promotes T-ALL evolution by deubiquitinating modified HIF1A
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. The potential of investigating USP20 holds promise for more targeted therapies and better outcomes. Knocking down USP20 led to decreased T-ALL cell survival and growth both in vitro and in vivo, similar to usi...
ORGANISM(S): Homo sapiens 
2025-08-31 | GSE267258 | GEO
TranscriptomicsDeubiquitinase USP20 promotes breast cancer metastasis by stabilizing SLUG
In the lung metastatic breast cancer MDA-MB231 subline LM2 cells, knockdown of USP20 results in similar changes of a list of migration/invasion-related genes as knockdown of SLUG, and SLUG protein is identified as a target of USP20 for deubiquitination.
ORGANISM(S): Homo sapiens 
2025-12-20 | GSE112017 | GEO
GenomicsRNA-seq for AML cell lines in either the absence or presence of USP20
RNA-seq for AML cell lines in either the absence or presence of USP20
PRJNA1244232 | ENA
UnknownHERC2-USP20 axis regulates DNA damage checkpoint through Claspin.
Not available
S-EPMC4245938 | biostudies-literature
UnknownHERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.
Not available
S-EPMC4245974 | biostudies-literature
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