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MetabolomicsAn Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection
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ORGANISM(S): Homo sapiens 
ST001921 | MetabolomicsWorkbench
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
TranscriptomicsGenome-wide Mapping of ARRB1 Reveals its Role as a HIF1A Transcriptional Co-regulator and Regulator of Cellular Metabolism [expression array]
Beta-arrestin 1 (ARRB1) has been implicated in transcriptional regulation as part of protein complexes bound to chromatin. Here we investigate its effect on transcription and its potential impact on prostate cancer. We report the first genome-wide mapping of chromatin binding for ARRB1 and combine i...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-55614 | biostudies-arrayexpress
TranscriptomicsHIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over the resting state. Although a role for the metabolic switch to glycolysis has been suggested to support increased anabolic activities and facilitate T cell growth and proliferation, whether cellular metabolism c...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29765 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild type and Hif1a-deficient normal and leukemia stem cells
This SuperSeries is composed of the following subset Series: GSE35110: Gene expression profiling in WT and Hif1a-/- HSCs GSE35111: Gene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Hif1a-/-LSCs Refer to individual Series
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35183 | biostudies-arrayexpress
GenomicsGenome-wide maps of HIF1a binding sites in ccRCC cell line under hypoxia condition
We report the application of chromatin immunoprecipitation and next generation sequencing technology for HIF1a binding sites at genome wide level in a RCC (renal cell carcinoma) cell line under hypoxia conditions. We found HIF1a binding sites in Caki-2 cell line under hypoxia conditions. Especiall...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-54327 | biostudies-arrayexpress
ProteomicsIdentify HILPS-interacting proteins and HIF1a phosphorylation sites
To dissect the molecular mechanisms of HILPS in promoting cell survival under hypoxia, we conducted RNA pull-down assay in combination with mass spectrometry analysis to identify HILPS-interacting proteins. Pull-down of antisense HILPS was used as a negative control. To identify the potential phosph...
ORGANISM(S): Homo sapiens (Human) 
2023-10-19 | PXD042226 | Pride
Human Lc-ms/ms 
GenomicsHif1a ChIP-Seq on P12 murine retina
We prformed ChIP-seq to identify Hif1a transcription factor binding site in mouse retina at postnatal day 12. Related data are in E-MTAB-9395 (scRNA-seq) and E-MTAB-9440 (ATAC-seq).
ORGANISM(S): Mus musculus 
2021-12-31 | E-MTAB-10407 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of transcriptomes of control and Hif1a mutant E12.5 hearts
Purpose: to identify genes aberrantly expressed upon myocardial ablation of Hif1a Methods: a floxed Hif1a allele was deleted in mouse embryonic hearts using a NXK2.5Cre line. Total RNA was extracted from E12.5 hearts (n=3 for controls and mutants) usinz Trizol and processed for RNA-seq. Reads were m...
ORGANISM(S): Mus musculus 
2015-04-29 | E-GEOD-61209 | biostudies-arrayexpress
ProteomicsLoss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis
Here we utilized a mouse model of PDAC and human pancreatic cancer cell lines to investigate the role of HIF1alpha in pancreatic cancer. Contrary to the conventional notion that HIF1alpha plays a tumor promoting role in several cancers, our findings indicate a tumor suppressive role of HIF1alpha in ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-21 | MSV000084223 | MassIVE
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