Proteomics

Dataset Information

0

USP20 promotes T-ALL evolution by deubiquitinating modified HIF1A

ABSTRACT: Qualitative analysis of proteome is to study the types and quantities of proteome identified by samples under different conditions, and to perform functional analysis of the identified proteins, so as to provide reference information for quantitative and modification analysis of high-throughput proteins.In order to explore how USP20 plays a role in T-ALL through deubiquitination, we investigated the substrate protein of USP0 by protein determination spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, T-cell Acute Lymphoblastic Leukemia Cell

DISEASE(S): Acute Leukemia

SUBMITTER: Zimu Zhang  

LAB HEAD: Ling Xu

PROVIDER: PXD053080 | Pride | 2025-10-13

REPOSITORIES: Pride

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Dataset's files

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Action DRS
XA06385LI_XLIgG.raw Raw
XA06385LI_XLflagusp20.raw Raw
XLIgG.zip Other
XLflagusp20.zip Other
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Publications

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy with a poor prognosis, despite advancements in treatment. Many patients struggle with relapse or refractory disease. Investigating the role of the super-enhancer (SE) regulated gene ubiquitin-specific protease 20 (<i>USP20</i>) in T-ALL could enhance targeted therapies and improve clinical outcomes. Analysis of histone H3 lysine 27 acetylation (H3K27ac) chromatin immunoprecipitation sequencing (ChIP-seq) da  ...[more]

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