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USP20 promotes T-ALL evolution by deubiquitinating modified HIF1A

ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. The potential of investigating USP20 holds promise for more targeted therapies and better outcomes. Knocking down USP20 led to decreased T-ALL cell survival and growth both in vitro and in vivo, similar to using the USP20 inhibitor GSK2643943A. To explore USP20-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the USP20-knockdown J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of USP20 with HIF1a on chromatin in J.gamma1 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE267258 | GEO | 2025/08/31

REPOSITORIES: GEO

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