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UnknownCTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway.
Not available
S-EPMC10158020 | biostudies-literature
UnknownExpression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.
Not available
S-EPMC3466302 | biostudies-literature
TranscriptomicsExpression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice
Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed myeloid precursor (e.g., a promyelocyte) vs. a hematopoietic stem/progenitor cell (HSPC). We original...
ORGANISM(S): Mus musculus 
2012-08-14 | GSE40022 | GEO
UnknownSerpinB1a induces hepatopulmonary syndrome by promoting CTSG/AMPK/mTOR pathway-mediated mitophagy.
Not available
S-EPMC12537609 | biostudies-literature
Genomics
CTSG RNA-seq in PC9 cell line
PRJNA1092588 | ENA
TranscriptomicsExpression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice
Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed myeloid precursor (e.g., a promyelocyte) vs. a hematopoietic stem/progenitor cell (HSPC). We original...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-40022 | biostudies-arrayexpress
GenomicsMus musculus
Expression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice
PRJNA172400 | ENA
TranscriptomicsTranscriptomic analysis by RNA-seq unveils distinct gene expression profile of U397 cells depleted of NSPs
Characterization of transcriptomic changes associated with genetic ablation of three neutrophil serine proteases (CTSG, ELANE, PRTN3). U937 cells depleted of CTSG, ELANE, and PRTN3 simultaneously (ΔNSPs) were generated using the CRISPR-Cas9 system and sgRNAs. RNA-Seq analysis revealed transcriptomic...
ORGANISM(S): Homo sapiens 
2021-04-02 | GSE142662 | GEO
TranscriptomicsmCG-PML-RARA alters multipotent hematopoiesis.
Acute promyelocytic leukemia (APL) is associated with PML-RARA expression and late myeloid maturation arrest. The myeloid restriction of PML-RARA dependent leukemia has been recapitulated in multiple mouse models of APL, including PML-RARA expressed from the Ctsg locus (mCG-PR). However, we report h...
ORGANISM(S): Mus musculus 
2010-10-21 | GSE24728 | GEO
TranscriptomicsT cells dressed up with a dual HLA-restricted TCR targeting Cathepsin G drive effective leukemia eradication
Despite immunosensitivity, genetic heterogeneity, low mutational burden and lack of tumor-specific antigens hinder immunotherapy success for acute myeloid leukemia (AML). T cell receptors (TCRs) offer a promising route by targeting tumor-relevant intracellular antigens shared across AML subtypes; ho...
ORGANISM(S): Homo sapiens 
2026-10-06 | GSE298290 | GEO
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