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ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054057 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
UnknownSelective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.
Not available
S-EPMC4027141 | biostudies-literature
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054041 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
UnknownStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor.
Not available
S-EPMC11812085 | biostudies-literature
UnknownAI/ML-Driven DPP-4 Inhibitor Predictor (d4p_v1) for Enhanced Type 2 Diabetes Mellitus Management: Insights Into Chemical Space, Fingerprints, and Electrostatic Potential Maps.
Not available
S-EPMC12455174 | biostudies-literature
UnknownSynthesis, radiolabeling, and evaluation of a (4-quinolinoyl)glycyl-2-cyanopyrrolidine analogue for fibroblast activation protein (FAP) PET imaging.
Not available
S-EPMC10086185 | biostudies-literature
UnknownEvaluation of the Drug-Induced Liver Injury Potential of Saxagliptin through Reactive Metabolite Identification in Rats.
Not available
S-EPMC10819019 | biostudies-literature
UnknownRadiosynthesis and First Preclinical Evaluation of the Novel 11C-Labeled FAP Inhibitor 11C-FAPI: A Comparative Study of 11C-FAPIs and (68Ga) Ga-DOTA-FAPI-04 in a High-FAP-Expression Mouse Model.
Not available
S-EPMC9388731 | biostudies-literature
UnknownDesign, Synthesis and Preclinical Assessment of 99mTc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging.
Not available
S-EPMC8746441 | biostudies-literature
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