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MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
TranscriptomicsBisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome wide association study was performed using 500.568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treat...
ORGANISM(S): Homo sapiens 
2008-09-25 | E-GEOD-11948 | biostudies-arrayexpress
ProteomicsBiotransformation of efavirenz and proteomic analysis of P450s and UGTs in human, mouse, and macaque brain-derived in vitro systems
Antiretroviral drugs such as efavirenz (EFV) are essential to combat HIV infection in the brain, but little is known about how these drugs are metabolized locally. In this study, the cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT)-dependent metabolism of EFV was probed in brain microsom...
ORGANISM(S): 9606 
2022-10-24 | MSV000090576 | MassIVE
TranscriptomicsCulex quinquefasciatus Jpal-per strain vs. Ogasawara strain
A pyrethroid-resistant strain of Culex quinquefasciatus, JPal-per, exhibits 2500-fold greater larval resistance to permethrin than the insecticide-susceptible strain Ogasawara. An increased microsome monooxygenase metabolism is involved in the resistance mechanism. Microarray analysis revealed alter...
ORGANISM(S): Culex quinquefasciatus 
2010-06-24 | E-GEOD-17326 | biostudies-arrayexpress
ProteomicsLong term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats
Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol a...
ORGANISM(S): Mus Musculus 
2025-04-27 | PXD063375 |
ProteomicsInduction of active hepatic cytochrome P450 enzymes in mice exposed to benzo[a]pyrene or environmental mixtures of polycyclic aromatic hydrocarbons
Cytochrome P450 enzymes play an important role in bioactivating or detoxifying polycyclic aromatic hydrocarbons (PAHs). We exposed mice to doses of benzo[a]pyrene (BaP) or a mixture of PAHs to characterize dose- and time-response relationships of specific cytochrome P450s. Mice exposed to the highes...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD019472 | Pride
Enyzme induction Chemoproteomics Polycyclic aromatic hydrocarbons Cytochrome p450 
ProteomicsFetal to adult ontogeny of human cytochrome P450 activity, abundance, and expression
Activity-based and global proteomic analysis of fetal through late adulthood human samples, with a primary focus on cytochrome P450 enzyme expression and functional activity
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002781 | Pride
Activity-based proteomics Ontogeny Cytochrome p450 
TranscriptomicsBeta-naphthoflavone treated worms
The soil nematode Caenorhabditis elegans is one of the simplest animals having the status of a laboratory model. Its genome contains 80 cytochrome P450 genes (CYP). In order to study CYP gene expression in C. elegans mixed stages and synchronized hermaphrodites were exposed to 18 known xenobiotic cy...
ORGANISM(S): Caenorhabditis elegans 
2005-11-25 | E-GEOD-3680 | biostudies-arrayexpress
ProteomicsIncreased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis
The cytochrome P450 limonene-6-hydroxylase (P450), cytochrome P450 reductase (CPR) and carveol dehydrogenase (CDH) were expressed in Escherichia coli for (−)-carvone production from (−)-limonene. The optimum ratio of enzyme expression to maximize (−)-carvone production was determined using the prote...
ORGANISM(S): Escherichia Coli 
2022-08-24 | PXD028077 | JPOST Repository
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