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UnknownEffectiveness of computerised alerts to reduce drug-drug interactions (DDIs) and DDI-related harm in hospitalised patients: a quasi-experimental controlled pre-post study.
Not available
S-EPMC12703349 | biostudies-literature
UnknownEvaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling.
Not available
S-EPMC12011704 | biostudies-literature
UnknownComparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs.
Not available
S-EPMC12706401 | biostudies-literature
TranscriptomicsSingle Cell Transcriptomics Reveals TGF-Beta and HMGA1 as Global Markers of Transcriptional Diversity in Cellular Senescence
Here, through single-cell transcriptional profiling of genetically homogenous clonal cell lines, we analyzed subpopulations in all three major forms of senescence, namely Oncogene Induced Senescence (OIS), Replicative Senescence (RS), and DNA Damage Induced Senescence (DDIS).
ORGANISM(S): Homo sapiens 
2023-05-04 | GSE173879 | GEO
TranscriptomicsNOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [CSM]
ER:RAS-G12V expressing IMR90 cells were treated with either 100nM 4-OHT for 6 days or 100uM Etoposide for 2 days, followed by further culture for 5 days, leading to RAS-induced senescence (RIS) and DNA-damage induced senescence (DDIS) respectively.
ORGANISM(S): Homo sapiens 
2016-06-22 | GSE72407 | GEO
UnknownDDIS-27. TARGETING ATP DOCKING AND P35/P25 BINDING OF CDK5 IN GLIOMA STEM CELLS USING SYNTHETIC INHIBITORS
Not available
S-EPMC6846902 | biostudies-literature
UnknownPrediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
Not available
S-EPMC9286715 | biostudies-literature
TranscriptomicsA new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle
Drug-drug interactions (DDIs), especially with herbal medicines, are complex, making it difficult to identify potential molecular mechanisms and targets. We introduce a workflow to carry out DDI research using transcriptome analysis and interactions of a complex herbal mixture, Compound Kushen Injec...
ORGANISM(S): Homo sapiens 
2019-08-20 | GSE130359 | GEO
UnknownPotentially clinically significant drug-drug interactions in older patients admitted to the hospital: A cross-sectional study.
Not available
S-EPMC9932507 | biostudies-literature
UnknownPrevalence and type of drug-drug interactions involving ART in patients attending a specialist HIV outpatient clinic in Kampala, Uganda.
Not available
S-EPMC4652684 | biostudies-literature
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