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NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [CSM]

ABSTRACT: ER:RAS-G12V expressing IMR90 cells were treated with either 100nM 4-OHT for 6 days or 100uM Etoposide for 2 days, followed by further culture for 5 days, leading to RAS-induced senescence (RIS) and DNA-damage induced senescence (DDIS) respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72407 | GEO | 2016/06/22

SECONDARY ACCESSION(S): PRJNA293984

REPOSITORIES: GEO

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NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [N1ICD]

Project description:ER:RAS-G12V expressing IMR90 cells were transduced with N1ICD-containing or control vectors before treatment with either 100nM 4-OHT or vehicle for 6 days leading to Notch-induced senescence (NIS), RAS-induced senescence (RIS) or combined Notch and Ras-induced senescence (RNIS).

2016-06-22 | GSE72404 | GEO

The effect of COX2 inhibition on RAS-induced senescence

Project description:ER:RAS-G12V expressing IMR90 cells were treated with either 100nM 4-OHT or 40uM Celecoxib or both for 6 days leading to RAS-induced senescence (RIS) with or without COX2 inhibition.

2021-01-25 | GSE145650 | GEO

Autophagy mediates the mitotic senescence transition

Project description:ER:RAS-G12V expressing IMR90 cells were given 100nM 4-OHT and assessed for transcriptional profiling at various time points. IMR90 cells expressing a 4-hydroxytamoxifen (4-OHT) inducible estrogen receptor (ER)-coupled RAS-G12V (ER:RAS-G12V) were given 100nM 4-OHT for these eight time points (0, 2, 8, 24hrs, 2, 4, 6 and 8days) then analysed for transcriptional profiling using the illumina expression array platform (human-6 v2 Expression BeadChips). There were three biological replicates (batch A, B and D) for each of the time points.

2014-07-31 | E-GEOD-59522 | biostudies-arrayexpress

Autophagy mediates the mitotic senescence transition

Project description:ER:RAS-G12V expressing IMR90 cells were given 100nM 4-OHT and assessed for transcriptional profiling at various time points.

2014-07-31 | GSE59522 | GEO

Effect of NMTi on senescence model systems

Project description:To examine effects of NMT inhibition on senescence transcriptional signatures we treated IMR90 ER:RAS cells with either IMP1088 (300nM) or DDD86481 (1.5uM) for 72h 7 days after induction with 4-OHT treatment. Transcriptional analysis was performed 3 days after drug treatment and 10 days after senescence induction.

2023-09-28 | GSE224071 | GEO

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [ATAC-Seq]

Project description:We describe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonizes the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonize the formation of RIS specific accessible regions.

2018-04-24 | GSE103588 | GEO

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [RNA-Seq]

Project description:We decribe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonises the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonise the formation of RIS specific accessible regions.

2018-04-24 | GSE113060 | GEO

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [ChIP-Seq]

2018-04-24 | GSE103589 | GEO

Gene expression profiles of Ras mutants.

2009-02-21 | GSE14934 | GEO

Gene expression profiles of Ras mutants.

Project description:Gene expression profiles were collected from HEK-HT cells expressing H-Ras with Ras-activating (G12V), Raf-activating (G12V,T35S), RalGEF-activating (G12V,E37G), or PI3K-activating (G12V,Y40C) mutations. Keywords: Comparison of Ras pathway components. THX=control; 12V=G12V mutation; 35S=G12V,T35S mutation; 37G=G12V,E37G mutation; 40C=G12V,Y40C mutation. 5 replicates of each. Total of 25 samples.

2009-02-21 | E-GEOD-14934 | biostudies-arrayexpress

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