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MetabolomicsAkkermansia muciniphila alleviates endoplasmic reticulum stress via activation of farnesoid X receptors in colitis

Endoplasmic reticulum (ER) stress-related mucin depletion could be involved in the pathogenesis of inflammatory bowel disease (IBD). Akkermansia muciniphila (A. muciniphila) uses mucin as its sole energy source and shows potential in the treatment of colitis. However, the effects and underlying m...

2025-10-09 | MTBLS13104 | MetaboLights
ModelsDeath Receptor Signaling
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including c...
2084 | Cell Collective
ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
PXD056836 |
TranscriptomicsDeath Receptors DR6 and TROY Regulate Brain Vascular Development
Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 and TROY/TNFRSF19 as regulators of CNS-specific angiogenesi...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-35802 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rice cells reveal bacterial lipopolysaccharides induce defense responses associated with programmed cell death
PAMP (Pathogen-Associated Molecular Pattern) recognition plays an important role in innate immune responses both in plants and animals. Lipopolysaccharides (LPS) of gram-negative bacteria are a typical PAMP molecule and have been reported to induce defense-related responses such as suppression of hy...
ORGANISM(S): Oryza sativa 
2008-11-06 | E-GEOD-5906 | biostudies-arrayexpress
TranscriptomicsDeath Receptors DR6 and TROY Regulate Brain Vascular Development
Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 and TROY/TNFRSF19 as regulators of CNS-specific angiogenesi...
ORGANISM(S): Mus musculus 
2012-02-15 | GSE35802 | GEO
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
TranscriptomicsTNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP
The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable ...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-10103 | biostudies-arrayexpress
GenomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
PTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
PRJNA1135166 | ENA
UnknownPhosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death.
Not available
S-EPMC3641334 | biostudies-literature
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