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MetabolomicsMetabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM

Most of pre-diabetes were eventually progress to diabetes, thereby profiling of prediabetic metabolic disorders may be an effective targeted preventive measure. We aimed to elucidate internal motivation of the progression of pre-diabetes to type 2 diabetes mellitus (T2DM) from a metabolic perspec...

2024-04-29 | MTBLS8644 | MetaboLights
MetabolomicsDisorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis co-morbid type 2 diabetes mellitus

BACKGROUND: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms ...

2023-12-15 | MTBLS8729 | MetaboLights
MetabolomicsEffects of herb DG and KK01 on Type 2 Diabetes Mellitus (T2DM) through Lipidomics
Not available
ORGANISM(S): Mus musculus 
ST000530 | MetabolomicsWorkbench
MetabolomicsSpatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

Spatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

2025-11-26 | MTBLS12782 | MetaboLights
MetabolomicsComprehensive analysis of the microbiome and metabolome in pus from pyogenic liver abscess patients with and without diabetes mellitus

Pyogenic liver abscess (PLA) patients combined with diabetes mellitus (DM) tend to have more severe clinical manifestations than without DM. The mechanism responsible for this phenomenon is not entirely clear. The current study therefore aimed to comprehensively analyze the microbiome composition...

2026-01-24 | MTBLS7128 | MetaboLights
TranscriptomicsCorrelation of Candidate Genetic Variations for Susceptibility and Risk Assessment of Type 2 Diabetes Mellitus and its Related Medical Conditions among Filipinos (DM2)
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-17412 | biostudies-arrayexpress
TranscriptomicsCorrelation of Candidate Genetic Variations for Susceptibility and Risk Assessment of Type 2 Diabetes Mellitus and its Related Medical Conditions among Filipinos (DM2)
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-17413 | biostudies-arrayexpress
MetabolomicsA metabolomic study of urinary changes in type 2 diabetes in human compared to the control group
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in ...
2012-02-14 | MTBLS1 | MetaboLights
MetabolomicsIntegration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in pulmonary tuberculosis and pulmonary tuberculosis-complicated diabetes

Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that threaten human health. Patients with DM are susceptible to PTB, an important factor that aggravates the complications of diabetes. However, the molecular regulatory mechanism underlying the susceptibility of ...

2023-07-26 | MTBLS7623 | MetaboLights
MetabolomicsIntra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes
In this study we explored a unique cohort of 43 samples to build a map of metabolites varying in T2D across five different tissues (subcutaneous adipose tissue, liver, pancreatic islets, skeletal muscle and blood serum). The samples originate from the Excellence in Diabetes biobank (EXODIAB) in Swed...
2018-10-08 | MTBLS690 | MetaboLights
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