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GenomicsTargeting the treponemal microbiome of digital dermatitis infections by deep coverage pyrosequencing
We examined 36 biopsies taken from digital dermatitis lesions of Holstein cows. The target was the V3 -V4 variable region of 16S rRNA using Treponema specific primers. We identified 20 different taxa of Treponema using this approach. Phylogenetic study of the Treponema taxa found in digital dermati...
ORGANISM(S): Bos taurus 
2013-06-25 | E-GEOD-42426 | biostudies-arrayexpress
TranscriptomicsIdentifying host pathogenic pathways in bovine digital dermatitis by RNA-Seq analysis of lesions
Digital dermatitis is a painful foot disease compromising welfare in dairy cattle. The disease has a complex multibacterial aetiology, but little is known about its pathogenesis. In this study, gene expression in skin biopsies from five bovine digital dermatitis lesions and five healthy bovine feet ...
ORGANISM(S): Bos taurus 
2013-03-26 | E-GEOD-41732 | biostudies-arrayexpress
TranscriptomicsChanges in transcription patterns in BoMac cells in response to PDD spirochetes
Papillomatous digital dermatitis (PDD) is a polymicrobial infection in soft tissue adjacent to the hoof and is the leading cause of lameness in dairy cattle. Treponema phagedenis-like (TPL) spirochetes are a constant feature of PDD lesions and are localized deep in infected tissue. Host-cell respon...
ORGANISM(S): Bos taurus 
2007-06-22 | E-GEOD-6702 | biostudies-arrayexpress
GenomicsDigital Dermatitis multimicrobial community
Multimicrobial community from lesion derived from bovine digital dermatitis Raw sequence reads
PRJNA317033 | ENA
GenomicsBovine metagenome digital dermatitis
Bovine metagenome digital dermatitis Metagenome
PRJNA478809 | ENA
ProteomicsProfiling the proteolytic dysfunction in digital dermatitis in cattle and the therapeutic use of a non-antimicrobial matrix metalloproteinase inhibitor
ABSTRACT Digital dermatitis (DD) is a painful inflammatory skin disease affecting the digital regions of cattle feet, linked to pathogenic Treponemes spp. This condition imposes a substantial economic burden on the cattle industry attributable to lameness and subsequent production inefficiencies. Cu...
ORGANISM(S): Bos taurus (Bovine) 
2025-09-19 | PXD060742 | Pride
: proteolytic dysfunction  metalloprotease inhibitor  oxytetracycline  digital dermatitis  cattle  treponema spp. 
GenomicsDigital Dermatitis in Norway
Treponema spp. associated with digital dermatitis in Norwegian cattle and development of a diagnostic qPCR
PRJEB102894 | ENA
ProteomicsAtopic dermatitis epidermis PCT-DIA
Atopic Dermatitis (AD) is the most common inflammatory skin disease and characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in AD pathogenesis, but the alterations in the proteome that occur in the entire epidermis have not b...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD025431 | Pride
Pressure cycling technology Atopic dermatitis Data-independent acquisition Epidermis 
Genomicsbovine metagenome
Digital dermatitis biopsies Targeted Locus
PRJNA179379 | ENA
TranscriptomicsIdentifying host pathogenic pathways in bovine digital dermatitis by RNA-Seq analysis of lesions
Digital dermatitis is a painful foot disease compromising welfare in dairy cattle. The disease has a complex multibacterial aetiology, but little is known about its pathogenesis. In this study, gene expression in skin biopsies from five bovine digital dermatitis lesions and five healthy bovine feet ...
ORGANISM(S): Bos taurus 
2013-03-26 | GSE41732 | GEO
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