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GenomicsGene expression profiling in diptoindonesin G-treated MDA-MB-231 cells
Gene expression profiling in diptoindonesin G-treated MDA-MB-231 cells
PRJNA623219 | ENA
GenomicsEffect of diptoindonesin G on T47D cells overexpressing the Y537S ER mutation
Effect of diptoindonesin G on T47D cells overexpressing the Y537S ER mutation
PRJNA847231 | ENA
ProteomicsDiptoindonesin G is a middle domain HSP90 modulator for cancer treatment
HSP90 inhibitors can target many oncoproteins simultaneously, but none have made it through clinical trials due to dose-limiting toxicity and induction of heat shock response, leading to clinical resistance. We identified diptoindonesin G (dip G) as an HSP90 modulator that can promote degradation of...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD035398 | Pride
Esr1  hsp90  heat shock  lbd mutations  diptoindonesin g  hsp90 inhibitor  y537s  hsp90 middle domain  er alpha 
TranscriptomicsGene expression profiling in diptoindonesin G-treated MDA-MB-231 cells
To understand the role of diptoindonesin G in the regulation of differentiation of breast cancer cells, the gene expression profile of MDA-MB-231 cells treated with diptoindonesin G was analyzed using Hiseq deep sequencing.
ORGANISM(S): Homo sapiens 
2020-08-26 | GSE148100 | GEO
TranscriptomicsEffect of diptoindonesin G on T47D cells overexpressing the Y537S ER mutation
To investigate the effect of diptoindonesin G on breast cancer cells expressing the estrogen receptor Y537S ligand binding domain mutation, we treated T47D cells overexpressing the ER Y537S mutation and treated them with vehicle or diptoindonesin G and performed differential gene expression analysis...
ORGANISM(S): Homo sapiens 
2022-06-11 | GSE205716 | GEO
UnknownDiptoindonesin G, a new Hsp90 drug.
Not available
S-EPMC9841029 | biostudies-literature
UnknownReciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G.
Not available
S-EPMC4767166 | biostudies-literature
UnknownDiptoindonesin G is a middle domain HSP90 modulator for cancer treatment.
Not available
S-EPMC9771721 | biostudies-literature
UnknownDiptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells.
Not available
S-EPMC5520695 | biostudies-literature
UnknownDiptoindonesin G antagonizes AR signaling and enhances the efficacy of antiandrogen therapy in prostate cancer.
Not available
S-EPMC9035130 | biostudies-literature
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