disease-associated microglia

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Organisms

Mus musculus (423)
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-- (1)
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CHEBI ID

CHEBI:132542 (1)
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CHEBI:183249 (1)
CHEBI:183804 (1)
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CHEBI:134587 (1)
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CHEBI:75555 (1)
CHEBI:28260 (1)

Metabolite Name

Lonchocarpol A (3)
Chlorantraniliprole (3)
Phenthoate (3)
Docetaxel (3)
Cerivastatin (3)
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Candesartan (3)
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Chicoric acid (3)
Phlorizin (3)
Arbutin (3)
Repaglinide (3)

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2014 (25)
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Study type

Transcription profiling by array (84)
RNA-seq of coding RNA (21)
RNA-seq of coding RNA from single cells (6)
ChIP-seq (3)
Other (2)
Methylation profiling by array (2)
Cell line - Single-cell sequencing (1)
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Release Date

2023 (329)
2025 (306)
2024 (293)
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2020 (192)
2018 (124)
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2015 (67)
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2008 (7)
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2001 (1)

Lab affiliation

DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (5)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (2)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (2)
Department of Neurology, Yale School of Medicine, Yale University, new haven CT, USA (2)
Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK. (2)
Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA (1)
Associate Professor of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (1)
Associate Professor, Department of Neurology, Yale University School of Medicine (1)
Bascom Palmer Eye Institute University of Miami (1)
Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia (1)
Center for Translational & Computational Neuroimmunology Department of Neurology 622 West 168th street New York, NY 10032 (1)
Charité – Universitätsmedizin Berlin, Germany (1)
Chiara Guerrera, IRHC, HDR Head of the Necker Proteomics Faculty of Medecine, University Paris Cité SFR Necker INSERM US24 160 rue de Vaugirard | 75015 Paris Tél. 01 40 61 54 6 (1)
Department of Chemistry, The Scripps Research Institute (1)
Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO USA (1)
Department of Neurology, Emory University, Atlanta, GA 30322, US (1)
Department of Neurology, Yale University, New Haven, CT, USA (1)
Department of Neuropathology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany (1)
Department of Pharmacology University of North Carolina (1)
Division of Systems Medicine, Imperial College London (1)
Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA 90095, USA (1)
Emory University School of Medicine Departments of Biochemistry and Neurology (1)
Imperial College London (1)
Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Am Klinikum1, 07747 Jena, Germany (1)
Institute of Innate Immunity, University Hospital Bonn (1)
Korea Brain Research Institute, Daegu, 41068, Korea (1)
LMU Munich, Department of Chemsitry (1)
Laboratory for the Research of Neurodegenerative Diseases, VIB Center for Brain & Disease Research, VIB, Leuven, Belgium (1)
Laboratory of Pediatrics, UMCG, The Netherlands (1)
Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Armenise 132, 200 Longwood Avenue, Boston, MA 02115, USA Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA (1)

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A neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights

Microglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights

Defining the microglia transcriptome in multifunctional protein-2 deficient mice

Purpose: We purified whole brain microglia of MFP2 knockout mice and control mice utilizing percoll gradient and FACS sorting, followed by microarray analysis to define the molecular changes in MFP2 knockout mice at the endstage of the disease. We compared the microglia transcriptome of Mfp2-/- micr...

ORGANISM(S): Mus musculus

2015-04-14 | E-GEOD-66420 | biostudies-arrayexpress

Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis

Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...

2026-06-01 | MTBLS14615 | MetaboLights

Interleukin-1 signaling is involved in local self-renewal and maintenance of microglia

During early embryogenesis microglia arise from yolk sac progenitors populating the developing CNS, where they are maintained as tissue-resident macrophages throughout the organism’s lifespan. Here, we describe an experimental system that allows the specific conditional ablation of microglia in vivo...

ORGANISM(S): Mus musculus

2015-07-15 | E-GEOD-68376 | biostudies-arrayexpress

RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease

Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain ...

ORGANISM(S): Mus musculus

2015-01-30 | E-GEOD-53789 | biostudies-arrayexpress

Defining the microglia transcriptome during disease progression in ALS transgenic mice

Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...

ORGANISM(S): Mus musculus

2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia (miRNA)

The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from miRNA gene expression microarrays; mRNA expression profiles obtained from the same RNA s...

ORGANISM(S): Mus musculus

2014-03-13 | E-GEOD-49330 | biostudies-arrayexpress

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia (mRNA)

The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from mRNA gene expression microarrays; miRNA expression profiles obtained from the same RNA s...

ORGANISM(S): Mus musculus

2014-03-13 | E-GEOD-49329 | biostudies-arrayexpress

Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia

Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...

ORGANISM(S): Mus musculus

2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress

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