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ProteomicsMultisite phosphorylation of intrinsically disordered region of Dishevelled
When WNT binds to its receptor Frizzled (FZD) to activate the signaling, Dishevelled (DVL), the central component of Wnt signaling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are k...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-04-07 | PXD063470 | Pride
Dishevelled Phosphorylation Hdx-ms 
ProteomicsComparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
Background: Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation generates complex barcodes underlying diverse DVL3 functions. ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015963 | Pride
Dishevelled/dvl3/phosphorylation/kinase/mass spectrometry/ck1/ttbk2/nek2/wnt 
ProteomicsDishevelled-3 protein conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we developed the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living...
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD013085 | Pride
Dishevelled Casein kinase 1 ɛ Conformation Phosphorylation Flash-based fret approach 
UnknownRegulation of Dishevelled DEP domain swapping by conserved phosphorylation sites.
Not available
S-EPMC8256032 | biostudies-literature
TranscriptomicsNucleoredoxin is required for the maintenance of Wnt/β-catenin signaling in mice embryo
We previously showed that nucleoredoxin (NRX) suppresses Wnt/β-catenin signaling through its binding to Dishevelled (Dvl) (Nat Cell Biol 8, 501-508 (2006)). To clarify the in vivo role of NRX in mammals, we here generate NRX gene-knockout mice (NRX-/- mice) by homologous recombination. NRX-/- mice ...
ORGANISM(S): Mus musculus 
2010-10-26 | E-GEOD-21954 | biostudies-arrayexpress
UnknownThe structural and functional determinants of the Axin and Dishevelled DIX domains.
Not available
S-EPMC2780430 | biostudies-literature
UnknownWnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
Not available
S-EPMC5065529 | biostudies-literature
UnknownDisinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.
Not available
S-EPMC4703060 | biostudies-literature
UnknownSelective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling.
Not available
S-EPMC9234668 | biostudies-literature
UnknownDishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity.
Not available
S-EPMC3432770 | biostudies-literature
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