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ProteomicsDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...
ORGANISM(S): Homo sapiens (Human) 
2019-02-26 | PXD012045 | Pride
Rna binding proteins  hnrnpd  dna damage  dna end resection  rna binding proteins  r-loop 
GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
GenomicsRole of CRY1 in DNA end resection
Role of CRY1 in DNA end resection
PRJNA1086926 | ENA
GenomicsDNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [END-seq]
DNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [END-seq]
PRJNA772573 | ENA
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
ProteomicsSAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) has a dNTPase-independent function in promoting DNA end resection to facilitate DNA double-strand break (DSB) repair by homologous recombination (HR); however, it is not known if upstream signaling events govern this activity. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031357 | Pride
Acetylation Ipms 
GenomicsDNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [ChIP-Seq]
DNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [ChIP-Seq]
PRJNA772575 | ENA
GenomicsEnd resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination
End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination
PRJNA1084733 | ENA
OtherDNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells [END-seq]
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G2 phases of the cell cycle partly due to 53BP1 antagonizing DNA end resection in G1 phase and non-cycling quiescent (G0) cells where DSBs must be repaired by non-homologous end joining (NHEJ). Unexpectedly, we...
ORGANISM(S): Mus musculus 
2022-05-16 | GSE186085 | GEO
GenomicsRole of CRY1 in DNA end resection
CRY1 is a circadian clock core component. Data in our laboratory has linked this factor with controlling the activity of the DNA double strand break repair protein CtIP, affecting the process of DNA end resection. By using ChIP-seq approaches in the DiVA cell system, we can show that the absence of ...
ORGANISM(S): Homo sapiens 
2025-08-19 | GSE261427 | GEO
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