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UnknownDNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer.

Objective

The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens.

Methods

Morphometric changes and somatic chromosomal ploidy status were assessed by ...
S-EPMC3062717 | biostudies-literature
UnknownModerate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis.
Global DNA hypomethylation is a most common epigenetic alteration in human neoplasia. However, accumulative evidence shows that global DNA hypomethylation impacts tumorigenesis in a tissue-specific manner, promoting tumorigenesis in some but suppressing tumorigenesis in others including colorectal c...
S-EPMC8096944 | biostudies-literature
UnknownDNA hypomethylation mediates immune response in pan-cancer.
Abnormal DNA methylation is a fundamental characterization of epigenetics in cancer. Here we demonstrate that aberrant DNA methylating can modulate the tumour immune microenvironment in 16 cancer types. Differential DNA methylation in promoter region can regulate the transcriptomic pattern of immune...
S-EPMC10038033 | biostudies-literature
UnknownGenome-wide DNA hypomethylation shapes nematode pattern-triggered immunity in plants.
A role for DNA hypomethylation has recently been suggested in the interaction between bacteria and plants; it is unclear whether this phenomenon reflects a conserved response. Treatment of plants of monocot rice and dicot tomato with nematode-associated molecular patterns from different nematode spe...
S-EPMC7317725 | biostudies-literature
UnknownThe genome-wide mutational consequences of DNA hypomethylation.
DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of subtelomeric, centromeric, and other inactive genomic regions. Carcinogenesis is ac...
S-EPMC10140063 | biostudies-literature
UnknownMechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Genomic hypomethylation is a consistent finding in both human and animal tumors and mounting experimental evidence suggests a key role for epigenetic events in tumorigenesis. Furthermore, it has been suggested that early changes in DNA methylation and histone modifications may serve as sensitive pre...
S-EPMC2571982 | biostudies-literature
UnknownOpposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.
Genome-wide DNA hypomethylation and concomitant promoter-specific tumor suppressor gene hypermethylation are among the most common molecular alterations in human neoplasia. Consistent with the notion that both promoter hypermethylation and genome-wide hypomethylation are functionally important in tu...
S-EPMC1224663 | biostudies-literature
UnknownDNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation.
Intestinal cancer is a heterogeneous disease driven by genetic mutations and epigenetic changes. Approximately 80% of sporadic colorectal cancers are initiated by mutation and inactivation of the adenomatous polyposis coli (APC) gene, which results in unrestrained intestinal epithelial growth and fo...
S-EPMC4930698 | biostudies-literature
UnknownUnique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma.
Global DNA hypomethylation is a characteristic feature of cancer cells that closely associates with chromosomal instability (CIN). However, the association between these characteristics during hepatocarcinogenesis remains unclear. Herein, we determined the relationship between hypomethylation and CI...
S-EPMC3759381 | biostudies-literature
UnknownParadoxical association of TET loss of function with genome-wide DNA hypomethylation.
Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread hypomethylation. Here, we show that TET loss of function results in a similar genomic footprint. Both 5hmC in wild-type (WT) genomes and DNA hypermethylation in TET-deficient genomes are large...
S-EPMC6708373 | biostudies-literature
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