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GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54191 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of naïve and in vitro effector CD8+ T cells from wild-type and BATF-/- mice
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54215 | biostudies-arrayexpress
ProteomicsSolvent-Induced partial Cellular Fixation Approach enables systematic identification of drug targets and temporal progression of downstream biochemical pathways in living cells
In this study, we introduce a novel approach, the Solvent-Induced Partial Cellular Fixation Approach (SICFA), to monitor drug targets and the temporal progression of downstream biochemical pathways in living cells. We observed that proteins in living cells undergo unfolding and aggregation when expo...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD057157 | Pride
Proteomics  protein stability  drug target identification  drug binding potency  downstream effector proteins  living cells analysis 
TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
UnknownThe GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle programme.
Not available
S-EPMC8547150 | biostudies-literature
UnknownProhibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling.
Not available
S-EPMC3762596 | biostudies-literature
GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastro...
ORGANISM(S): Mus musculus 
2014-03-02 | GSE54191 | GEO
UnknownCdc42/Rac Interactive Binding Containing Effector Proteins in Unicellular Protozoans With Reference to Human Host: Locks of the Rho Signaling.
Not available
S-EPMC8847673 | biostudies-literature
ProteomicsSKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function
Background: The importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orchestrate this response remain incompletely understo...
ORGANISM(S): Homo sapiens (Human) 
2024-02-16 | PXD048758 | Pride
Phagocytosis Src kinase associated phosphoprotein 2 (skap2) Cd11b/cd18 integrin Filamentous actin Antibody-dependent cellular cytotoxicity (adcc) Adhesion Neutrophils 
TranscriptomicsExpression data of A2EN cells during early stage of Chlamydia trachomatis infection
Chlamydia trachomatis is an obligate intracellular pathogen that causes trachoma and sextually transmitted disease in human. During early stage of infection, Chlamydia secreted bacterial effector proteins into host cell cytoplasm to help its entry and estabilishment of early replicated niche. We ide...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-54336 | biostudies-arrayexpress
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