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MetabolomicsMultiomics analysis of neutrophils in SLE: insights from adult and pediatric disease

Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through ROS and NET production, and increased apoptotic debris which causes autoantibody production and immune complex formation. These processes drive inflammation and tissue damage. The aim of this study was to perform in...

2026-04-22 | MTBLS6259 | MetaboLights
Metabolomics1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty
Neutrophil function declines with age, but little is known about the changes in neutrophil metabolism that take place in robust older people and older people with frailty. We used 1H-NMR spectroscopy to investigate the metabolomic and lipidomic profiles of blood neutrophils from healthy y...
2026-03-26 | MTBLS6055 | MetaboLights
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
MetabolomicsThe Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is ...

2021-12-03 | MTBLS2288 | MetaboLights
TranscriptomicsGenomic modulators of gene expression in human neutrophils
Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genetical genomic approaches to date. Here, we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 ...
ORGANISM(S): Homo sapiens 
2015-05-04 | E-MTAB-3536 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neutrophils obtained after exposure endotoxin by bronchoscopic instillation reveals differential gene expression between air space and circulating neutrophils
Although the accumulation of neutrophils in the lungs and airways is common to many inflammatory lung diseases, including acute lung injury, the alterations that neutrophils undergo as they leave the peripheral circulation and migrate into the lungs have not been well characterized. Human volunteers...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2322 | biostudies-arrayexpress
MetabolomicsGlobal metabolomics analysis of neutrophils isolated from tumor
Not available
ORGANISM(S): Mus musculus 
ST002160 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of Aspergillus fumigatus hyphae and conidia after incubation with neutrophils from different donors
Hyphae and conidia, representing the two developmental stages of the fungus, were examined separately in this study.

RNA from hyphae or conidia incubated in plasma in RPMI/HEPES without neutrophils was used as reference, and was co-hybridized with the query samples obtained from the correspon...
ORGANISM(S): Aspergillus fumigatus 
2008-09-25 | E-MEXP-1722 | biostudies-arrayexpress
TranscriptomicsPGN induced transcriptional changes in human neonatal neutrophils
We have employed whole genome microarray expression profiling to identify genes differentially expressed in cord blood purified neutrophils after a short-term exposure to peptidoglycan (PGN). PGN induced gene expressions of neonatal neutrophils were measured at 4 hours. Three biological replicates w...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-GEOD-40636 | biostudies-arrayexpress
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