drug targets in neurodegeneration

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1Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA (1)
Alzheimer’s Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, U.K. (1)
Center for Translational & Computational Neuroimmunology Department of Neurology 622 West 168th street New York, NY 10032 (1)
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Blood transcriptomics of drug-naive sporadic Parkinson'?s disease patients

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provid...

ORGANISM(S): Homo sapiens

2015-10-29 | E-GEOD-72267 | biostudies-arrayexpress

The proteostasis network provides targets for neurodegeneration.

Not available

S-EPMC6715599 | biostudies-literature

Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets.

Not available

S-EPMC10778851 | biostudies-literature

Transcriptomics-based drug repositioning in a neurocysticercosis rat model identifies putative therapeutic candidates reported to mitigate neuroinflammation and neurodegeneration

Neurocysticercosis (NCC) is a major cause of epilepsy and neurological symptoms in low- and middle-income countries. Although antiparasitic treatment targets the parasite, it often fails to fully resolve symptoms and can exacerbate brain tissue damage. Using a rat model of NCC and transcriptomic pro...

ORGANISM(S): Rattus norvegicus

2026-08-26 | GSE306561 | GEO

Network pharmacology-based identification of potential drug targets and bioactive compounds in Lycii Fructus (Gouqizi) for the therapeutics of Parkinson's disease.

Not available

S-EPMC12833033 | biostudies-literature

Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration.

Not available

S-EPMC10973195 | biostudies-literature

Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons.

Not available

S-EPMC8963304 | biostudies-literature

Transgenic animal models of neurodegeneration based on human genetic studies.