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Mechanistic insights into small-molecule inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and dSTORM
Upon entering in contact with the biological environment, nanostructures are immediately covered by biomolecules, and in particular proteins forming the so-called “protein corona” (PC). The phenomenon of PC formation has gained great attention in recent years due to its implication for the use of na...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031034 | Pride
The HuR small-molecule inhibitor MS-444 has been used in many cancer treatment studies, but its reproductive toxicity in females is unknown.Here, we used low-input RNA-seq and dSTORM to reveal the molecular mechanism and nanoscale organization changes by which MS-444 arrests embryonic development at...
ORGANISM(S): Mus musculus 
2023-09-20 | GSE192494 | GEO
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