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MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
ProteomicsDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Supporting data for "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model", DOI: T.B.D. Related to Figure 4A and S4A-B. KN43-66 - TMTpro | 4plex | Whole cell proteome - MS3 KN67-72 - TMTpro | 4plex | Enriched Phospho-peptides - MS2 K...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090202 | MassIVE
TranscriptomicsGene expression profile of sporadic and PSEN1 early-onset Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Around 10% of cases present an age of onset before 65 years-old, which in turn can be divided in monogenic or familial AD (FAD) and sporadic early-onset AD (EOAD). Mutations in PSEN1, PSEN2 and APP genes have been linked with FA...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-39420 | biostudies-arrayexpress
GenomicsHistone deacetylation-dependent and -independent transcriptional dysregulation in early-onset polyglutamine disease
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44854 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of placenta from women who underwent a normal pregnancy and from those suffering from early or late onset pre-eclampsia
Pre-eclampsia is one of the most serious pregnancy-associated disorders, and is defined by hypertension (systolic blood pressure higher than 140mmHg or diastolic blood pressure higher than 90mmHg) with proteinuria (more than 0.3g/day). It is not a simple complication of pregnancy, but is rather a sy...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-4707 | biostudies-arrayexpress
TranscriptomicsGeneration of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
This SuperSeries is composed of the following subset Series: GSE29772: CNV analysis for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations GSE29773: Gene Expression Data for Generation of isogenic pluripotent stem cells differing exclusiv...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-29774 | biostudies-arrayexpress
GenomicsEarly Onset Malignancies Initiative
Early Onset Malignancies Initiative
PRJNA597502 | ENA
GenomicsEarly Onset Malignancies Initiative
Early Onset Malignancies Initiative
PRJNA597501 | ENA
GenomicsEarly onset colorectal cancer tissues and late onset colorectal cancer tissues
Early onset colorectal cancer tissues and late onset colorectal cancer tissues
PRJNA879084 | ENA
GenomicsImmune profiles of early onset vs late onset colorectal cancer
Immune profiles of early onset vs late onset colorectal cancer
PRJNA732397 | ENA
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