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MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
TranscriptomicsPrognostic Gene-Expression Signature for Patients with Hepatitis CRelated Early-Stage Cirrhosis
Gene-expression profiles of hepatitis C-related, early-stage liver cirrhosis Background & Aims: Liver cirrhosis affects 1%M-bM-^HM-^R2% of population and is the major risk factor of hepatocellular carcinoma (HCC). Hepatitis C cirrhosis-related HCC is the most rapidly increasing cause of cancer deat...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-15654 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa lasR mutants in young cystic fibrosis patients
Pseudomonas aeruginosa undergoes genetic change during chronic infection of the airways of cystic fibrosis (CF) patients. One common change is mutation of lasR. LasR is a transcriptional regulator that responds to one of the quorum sensing signals in P. aeruginosa, and regulates acute virulence fa...
ORGANISM(S): Pseudomonas aeruginosa 
2010-06-30 | E-GEOD-5560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseuodomonas aeruginosa cystic fibrosis (CF) isolates
To provide a more detailed survey of adaptive changes in the physiology of P. aeruginosa (PA) during long-term infection of the cystic fibrosis (CF) lung, we performed a comparative proteome and transcriptome analysis of a set of isogenic sequential non-mutator and mutator isolates from three select...
ORGANISM(S): Pseudomonas aeruginosa 
2009-06-08 | E-GEOD-10362 | biostudies-arrayexpress
GenomicsEarly-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1+ macrophages
Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1+ macrophages
PRJNA1060696 | ENA
ProteomicsProteomics and phosphoproteomics reveal dysregulated kinases and associated pathway in liver fibrosis
Liver fibrosis is the initial stage of most liver diseases, and it is also a pathological process involving the liver in the late stages of many metabolic diseases. Therefore, it is important to systematically understand the pathological mechanism of liver fibrosis and seek therapeutic approaches fo...
ORGANISM(S): Mus Musculus 
2025-01-16 | PXD059906 |
UnknownGlobal analysis of DNA methylation in early-stage liver fibrosis.
Not available
S-EPMC3295686 | biostudies-literature
TranscriptomicsA genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54102 | biostudies-arrayexpress
GenomicsMapping vascular plasticity in liver fibrogenesis identifies novel fibrosis-associated endothelial cells in early-stage liver disease
Mapping vascular plasticity in liver fibrogenesis identifies novel fibrosis-associated endothelial cells in early-stage liver disease
PRJNA1474558 | ENA
UnknownHigher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients.
Not available
S-EPMC10468528 | biostudies-literature
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