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TranscriptomicsECM-dependent gene expression in normal and tumor-derived mammary organoids
A critical step in metastasis is cancer cell dissemination. Dissemination and metastasis are associated with specific genetic changes and changes in extracellular matrix (ECM), but how these changes interact to enable dissemination remains unclear. Here we tested the importance of ECM to disseminat...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-39173 | biostudies-arrayexpress
ProteomicsAcellular ECM Proteomics: Versican expression from lung fibroblasts is an autologous fibrotic brake
The activation and accumulation of lung fibroblasts, leading to excessive extracellular matrix (ECM) deposition, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis (IPF), a lethal and currently incurable disease. The collagen-rich fibrotic ECM perpetuates fibroblast activation and accumulatio...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD063546 | Pride
Aecm Pulmonary fibrosis  extracellular matrix (ecm)  lung fibroblasts  podosomes  ecm invasion  versican (vcan)  hyaluronan (ha)  collagens 
GenomicsELK3 controls gastric cancer cell migration and invasion by regulating ECM remodeling-related genes
ELK3 controls gastric cancer cell migration and invasion by regulating ECM remodeling-related genes
PRJNA753553 | ENA
TranscriptomicsTranscription profiling by array of human breast epithelium and stroma in normal reduction mammoplasty and invasive breast cancer patients
The molecular basis of breast cancer invasion and metastasis is not well understood. Our objective was to analyze transcriptome differences between stromal and epithelial cells in normal breast tissue and invasive breast cancer to define the role stroma plays in invasion. Total RNA was isolated fr...
ORGANISM(S): Homo sapiens 
2009-03-07 | E-GEOD-10797 | biostudies-arrayexpress
UnknownIntegrin-Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium.
Not available
S-EPMC12849879 | biostudies-literature
UnknownProteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization.
Not available
S-EPMC4735823 | biostudies-literature
UnknownAn in vitro model of cancer invasion with heterogeneous ECM created with droplet microfluidics.
Not available
S-EPMC10702358 | biostudies-literature
UnknownStromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling.
Not available
S-EPMC4815985 | biostudies-literature
TranscriptomicsELK3 controls gastric cancer cell migration and invasion by regulating ECM remodeling-related genes
Current therapeutic strategies, including surgery and chemotherapy, for gastric cancer improve survival; however, the survival rate for those with metastatic gastric cancer is very low. The molecular mechanisms underlying dissemination of gastric cancer cells to distant organs are unknown. Here, we ...
ORGANISM(S): Homo sapiens 
2021-09-14 | GSE181840 | GEO
ProteomicsCharacterization of Chemotherapy-treated PyMT Liver Matrisome
Metastasis accounts for 90% of cancer-related deaths, yet the mechanisms by which cancer cells colonize secondary organs remain poorly understood. For breast cancer patients, metastasis to the liver is associated with poor prognosis and a median survival of 6 months. Standard of care is chemotherapy...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-05 | PXD036736 | Pride
Breast cancer Mouse Liver metastasis 
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