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MetabolomicsMetabolomic responses of Solanum lycopersicum to Tuta absoluta infestation and TaCRVP effector expression
This study presents the metabolomic profiling of Solanum lycopersicum in response to feeding by the herbivorous insect Tuta absoluta and the overexpression of its salivary effector, TaCRVP. To elucidate how this effector manipulates host immunity at the metabolic level, we performed untargeted LC-MS...
2026-05-18 | MTBLS14509 | MetaboLights
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
MetabolomicsIdentification of effector metabolites using exometabolite profiling of diverse microalgae
Not available
ORGANISM(S): Chlamydomonas reinhardtii;Desmodesmus sp.;Phaeodactylum tricornutum;Microchloropsis salina 
ST001912 | MetabolomicsWorkbench
MetabolomicsUse of Integrated Metabolomics, Transcriptomics, and Signal Protein Profile to Characterize the Effector Function and Associated Metabotype of Polarized Macrophage Phenotypes
Not available
ORGANISM(S): Homo sapiens 
ST001835 | MetabolomicsWorkbench
TranscriptomicsComparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice
We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human effector CD8+ T cell subsets
Effector CD8+ T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector cytokines such as INF-M-NM-3 and TNF-M-NM-1. We investigated the difference between CXCR1+ and CXCR1- subsets of human effector CD27-CD28-CD8+ T cells. Both subsets...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-26890 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54191 | biostudies-arrayexpress
GenomicsGlobal DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function
In response to acute infection CD8 T cells differentiate into effector cells capable of clearing the antigen. While the transcriptional and functional changes have previously been studied little is known of the epigenetic modifications that accompany this differentiation process. To gain insights ...
ORGANISM(S): Mus musculus 
2013-08-18 | E-GEOD-44638 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific i...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TABM-40 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of effector T cells
This SuperSeries is composed of the following subset Series: GSE29606: Gene expression profiles of effector T cells induced by mTOR inhibition GSE29607: Comparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice Refer to individual Series
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-29608 | biostudies-arrayexpress
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