Sort   by:  
 Page size 
ProteomicsDe novo heterozygous variants in EHMT2 cause a novel Kleefstra related syndrome via loss of G9a methyltransferase activity
EHMT1 and EHMT2 genes encode human euchromatin histone lysine methyltransferase 1 and 2 (EHMT1 alias GLP; EHMT2 alias G9a) that form heteromeric GLP/G9a complexes with essential roles in epigenetic regulation of gene expression. While EHMT1 haploinsufficiency has been established as the cause of Kle...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD076523 | Pride
Ehmt2 Kleefstra syndrome 1 G9a proteins Ehmt1 
GenomicsThe role of EHMT2 in Uveal melanoma progression [EHMT2_Inhibitors]
The role of EHMT2 in Uveal melanoma progression [EHMT2_Inhibitors]
PRJNA806658 | ENA
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71422 | biostudies-arrayexpress
ProteomicsDNA damage stress control is a tLT- and EHMT2-dependent central feature of Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. Merkel cell polyomavirus (MCPyV) is the etiology of 80% of MCC cases via expression of the viral oncogenes small T antigen (sT) and truncated large T antigen (tLT). These proteins impair the Rb1-dependent G1/S check...
ORGANISM(S): Homo sapiens (Human) 
2024-06-04 | PXD044782 | Pride
Merkel cell carcinoma  truncated lt  ehmt2  proximal interactomics  proteome analysis  dna damage repair signaling. 
GenomicsGenome-wide binding of EHMT2 in RD18 ERMS cells
Genome-wide binding of EHMT2 in RD18 ERMS cells
PRJNA518103 | ENA
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
GenomicsTargeting EHMT2 Enhances NK Cell Maturation and Antitumor Activity [CUT&Tag]
Targeting EHMT2 Enhances NK Cell Maturation and Antitumor Activity [CUT&Tag]
PRJNA1441558 | ENA
GenomicsTargeting EHMT2 Enhances NK Cell Maturation and Antitumor Activity [RNA-Seq]
Targeting EHMT2 Enhances NK Cell Maturation and Antitumor Activity [RNA-Seq]
PRJNA1441560 | ENA
GenomicsEHMT2-mediated chromatin reprogramming in 5-fluorouracil (5-FU) resistant colorectal cancer
EHMT2-mediated chromatin reprogramming in 5-fluorouracil (5-FU) resistant colorectal cancer
PRJNA1392903 | ENA
Sort   by:  
 Page size