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TranscriptomicsA methyltransferase EHMT1 controls brown adipose cell fate and adaptive thermogenesis through a PRDM16 complex
Brown adipose tissue (BAT) dissipates chemical energy in the form of heat, as a defense against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from Myf5+-dermotomal precursors through the action of a PRDM16-C/EBP-_ transcriptional complex; however, the underlying mec...
ORGANISM(S): Mus musculus 
2013-11-07 | E-MTAB-1704 | biostudies-arrayexpress
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
ProteomicsMulti-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptionalrepression during oogenesis
EHMT1 (also known as GLP) is a multifunctional protein, best known for its role as an H3K9me1 and H3K9me2 methyltransferase through its reportedly obligatory dimerization with EHMT2 (also known as G9A). Here, we investigated the role of EHMT1 in the oocyte in comparison to EHMT2 using oocyte-specifi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-30 | PXD030265 | Pride
Epigenetics Histone modification Histone methyltransferase Glp/ehmt1 H3k9 methylation Dna methylation Oocyte 
GenomicsRole of EHMT1 in Alveolar Rhabdomyosarcoma
Role of EHMT1 in Alveolar Rhabdomyosarcoma
PRJNA742016 | ENA
TranscriptomicsHistone methylation by the Kleefstra Syndrome protein EHMT1 mediates homeostatic synaptic scaling.
Homeostatic plasticity, a form of synaptic plasticity, maintains the fine balance between overall excitation and inhibition in developing and mature neuronal networks. Although the synaptic mechanisms of homeostatic plasticity are well characterized, the associated transcriptional program remains po...
ORGANISM(S): Rattus norvegicus 
2016-06-30 | E-GEOD-68960 | biostudies-arrayexpress
GenomicsPost-natal supply of GLP/Ehmt1 reverses Histone H3K9 dimethylation in cortical neuron isolated from adult Ehmt1∆/+ mice brain
Post-natal supply of GLP/Ehmt1 reverses Histone H3K9 dimethylation in cortical neuron isolated from adult Ehmt1∆/+ mice brain
PRJNA681530 | ENA
GenomicsTargeting EHMT1/2 in colorectal cancer
Targeting EHMT1/2 sensitizes colorectal cancer to pan-HDAC inhibitors
PRJEB39827 | ENA
GenomicsEHMT1 mediates cellular motility in embryonal rhabdomyosarcoma by activating SOX8 expression.
EHMT1 mediates cellular motility in embryonal rhabdomyosarcoma by activating SOX8 expression.
PRJNA1146484 | ENA
GenomicsEHMT1/2 knockout induces a broad interferon signature
EHMT1/2 knockout induces a broad interferon signature
PRJNA1471972 | ENA
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