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GenomicsPost-natal supply of GLP/Ehmt1 reverses Histone H3K9 dimethylation in cortical neuron isolated from adult Ehmt1∆/+ mice brain
Post-natal supply of GLP/Ehmt1 reverses Histone H3K9 dimethylation in cortical neuron isolated from adult Ehmt1∆/+ mice brain
PRJNA681530 | ENA
ProteomicsIdentification of proteins stably associated with G9a/GLP (EHMT2/EHMT1) complex of histone methyltransferases
G9a (EHMT2) and the G9a-like protein GLP (EHMT1) form a stable G9a/GLP heterodimer in embryonic stem cells and function cooperatively to establish and maintain the abundant repressive H3K9me2 modification, in addition to modifying several non-histone proteins. The G9a-dependent H3K9me2 is implicated...
ORGANISM(S): Mus musculus (Mouse) 
2016-03-16 | PXD003466 | Pride
Shotgun proteomics G9a/glp (ehmt2/ehmt1) complex Embryonic stem cells Histones Mouse Chromatin 
GenomicsPost-natal supply of GLP/Ehmt1 reverses Histone H3K9 dimethylation in cortical neuron isolated from adult Ehmt1∆/+ mice brain
EHMT1 haploinsufficiency causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability. EHMT1 encodes a lysine methyltransferase GLP and regulates histone H3 lysine 9 dimethylation (H3K9me2). Ehmt1 heterozygous mutant (Ehmt1∆/+) mice show KS-like abnormal beha...
ORGANISM(S): Mus musculus 
2021-06-09 | GSE162327 | GEO
UnknownDe novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a.
Not available
S-EPMC9677696 | biostudies-literature
UnknownDemethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression.
Not available
S-EPMC10470473 | biostudies-literature
UnknownHistone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma.
Not available
S-EPMC6882350 | biostudies-literature
ProteomicsMulti-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptionalrepression during oogenesis
EHMT1 (also known as GLP) is a multifunctional protein, best known for its role as an H3K9me1 and H3K9me2 methyltransferase through its reportedly obligatory dimerization with EHMT2 (also known as G9A). Here, we investigated the role of EHMT1 in the oocyte in comparison to EHMT2 using oocyte-specifi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-30 | PXD030265 | Pride
Epigenetics Histone modification Histone methyltransferase Glp/ehmt1 H3k9 methylation Dna methylation Oocyte 
GenomicsLysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer
PRJNA832966 | ENA
ProteomicsDe novo heterozygous variants in EHMT2 cause a novel Kleefstra related syndrome via loss of G9a methyltransferase activity
EHMT1 and EHMT2 genes encode human euchromatin histone lysine methyltransferase 1 and 2 (EHMT1 alias GLP; EHMT2 alias G9a) that form heteromeric GLP/G9a complexes with essential roles in epigenetic regulation of gene expression. While EHMT1 haploinsufficiency has been established as the cause of Kle...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD076523 | Pride
Ehmt2 Kleefstra syndrome 1 G9a proteins Ehmt1 
TranscriptomicsDerepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra Syndrome
Kleefstra syndrome (KS, also known as 9q.34.3 deletion syndrome) is a rare genetic disorder characterized by a developmental delay, abnormal behaviors and autism-like features. This syndrome is caused by haplo-insufficiency of the euchromatin histone methyltransferase 1 gene (EHMT1/GLP/KDM1D). This ...
ORGANISM(S): Mus musculus 
2021-06-11 | GSE162934 | GEO
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