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TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
TranscriptomicsSETDB1 Represses Endogenous and Exogenous Retroviruses in B Lymphocytes [RNA-Seq]
Genome stability relies on epigenetic mechanisms that enforce repression of endogenous retroviruses (ERVs). Current evidence suggests that distinct chromatin-based mechanisms repress ERVs in cells of embryonic origin (histone methylation-dominant) versus more differentiated cells (DNA methylation-do...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-69464 | biostudies-arrayexpress
TranscriptomicsBovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis)
Background: Prion diseases such as bovine spongiform encephalopathies (BSE) are transmissible neurodegenerative diseases which are presumably caused by an infectious conformational isoform of the cellular prion protein. Previous work has provided evidence that in murine prion disease the endogenous ...
ORGANISM(S): Macaca fascicularis 
2011-06-10 | E-GEOD-29818 | biostudies-arrayexpress
UnknownTracking the Continuous Evolutionary Processes of an Endogenous Retrovirus of the Domestic Cat: ERV-DC.
Not available
S-EPMC5923473 | biostudies-literature
GenomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (Chip-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56567 | biostudies-arrayexpress
TranscriptomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (RNA-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56568 | biostudies-arrayexpress
UnknownERV-L elements: a family of endogenous retrovirus-like elements active throughout the evolution of mammals.
Not available
S-EPMC104094 | biostudies-literature
UnknownThe LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans.
Not available
S-EPMC321762 | biostudies-literature
UnknownPhysiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population.
Not available
S-EPMC109847 | biostudies-literature
UnknownFurther varieties of ancient endogenous retrovirus in human DNA.
Not available
S-EPMC11905727 | biostudies-literature
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