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TranscriptomicsA single cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs), lining blood vessels, across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomic data from 11 tissues of the model organism Mus musculus. We propose a new classification of EC phenotypes based on transcri...
ORGANISM(S): Mus musculus 
2020-02-13 | E-MTAB-8077 | biostudies-arrayexpress
TranscriptomicsIn vivo endothelial transcriptional profiles of porcine coronary and iliac arteries
Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity, we used DNA microarrays to compare gene expression profiles of freshly harvested po...
ORGANISM(S): Sus scrofa 
2010-06-20 | E-GEOD-10938 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human donor-matched retinal and choroidal vascular endothelial cells
Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7850 | biostudies-arrayexpress
TranscriptomicsMicrovascular endothelial heterogeneity
The goal of this study was to gain insight into the molecular heterogeneity of capillary endothelial cells derived from different organs by microarray profiling of freshly isolated cells and identify transcription factors that may determine the specific gene expression profile of endothelial cells f...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-48209 | biostudies-arrayexpress
TranscriptomicsEndothelial cell heterogeneity in pathological angiogenesis characterized by metabolic transcriptome diversity
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor and choroidal neovascularization (CNV), but little is known about individual EC metabolic transcrip-tomes. Here, by scRNA-sequencing 28,337 murine choroidal ECs (CECs) and sprouting CNV-ECs, we constructed a ...
ORGANISM(S): Homo sapiens 
2020-03-31 | E-MTAB-8604 | biostudies-arrayexpress
GenomicsMERFISH reveals embryonic endothelial heterogeneity
MERFISH reveals embryonic endothelial heterogeneity
PRJNA1038713 | ENA
TranscriptomicsUnraveling Transcriptomic Heterogeneity in the Human Dermal Blood Vascular Endothelium at Single-Cell Resolution
Our single-cell transcriptomic profiling study depicted the heterogeneity of human dermal blood vascular endothelial cells and molecularly refined individual blood vessel compartments.
ORGANISM(S): Homo sapiens 
2022-05-26 | E-MTAB-10137 | biostudies-arrayexpress
GenomicsIn Vivo Endothelial Cell Heterogeneity
In Vivo Endothelial Cell Heterogeneity
PRJNA203650 | ENA
TranscriptomicsSingle cell sequencing of renal endothelial cell heterogeneity and metabolic transcriptome adaptation to dehydration.
Renal endothelial cells (RECs) from glomerular cortical and medullary kidney compartments are exposed to different microenvironmental conditions. Upon dehydration medullary RECs (mRECs) are exposed to extreme hyperosmolarity. However the heterogeneous phenotypes of RECs remain in-completely inventor...
ORGANISM(S): Mus musculus 
2019-12-12 | E-MTAB-8145 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing data of zebrafish lymphatic and venous endothelial cells at different developmental stages (36 hpf, 48 hpf, 120 hpf (5 dpf) and 168 hpf (7 dpf))
This dataset contains single-cell RNA sequencing (scRNA-seq) profiles of zebrafish venous and lymphatic endothelial cells across development. Endothelial cells were isolated by FACS from transgenic zebrafish embryos and larvae at 36 hpf, 48 hpf, 5 dpf (120 hpf), and 7 dpf (168 hpf) using endothelial...
ORGANISM(S): Danio rerio 
2026-09-28 | E-MTAB-16797 | biostudies-arrayexpress
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