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GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
GenomicsChIP-seq for EP300 and H3K4me1 in the mouse melanocyte cell line melan-a
Using ChIP-seq for p300 and H3K4me1, we identified 2,489 putative melanocyte enhancer loci in the mouse genome. We demonstrated that these putative enhancers are evolutionarily constrained, enriched for sequence motifs predicted to bind key melanocyte transcription factors, located near genes releva...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-38498 | biostudies-arrayexpress
GenomicsEP300 genomic binding analysis in MCF7 cells with E-cadherin inhibition using ChIP-seq
This experiment examines the genomic binding of EP300 in MCF7 breast cancer cells after E-cadherin inhibition. Using ChIP-seq, we identified EP300 binding sites in control (cAb-MCF7) and E-cadherin-inhibited (nAb-MCF7) cells. The goal was to understand how EP300's chromatin binding is altered and it...
ORGANISM(S): Homo sapiens 
2025-06-03 | E-MTAB-15109 | biostudies-arrayexpress
ProteomicsIntensive lifestyle intervention modulates white adipose glycolipid metabolism via protein acetylation associated with Ep300
The homeostatic regulation of white adipose tissue (WAT) is crucial for maintain energy and metabolism balance. Plenty of clinical trials proved that intensive lifestyle intervention (ILI) improved fat accumulation in patients with obesity. Yet the underlying acetylated regulations of WAT during ILI...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD046768 | Pride
White adipose tissue  acetylation modification  obesity  intensive lifestyle intervention  ep300 
TranscriptomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]
Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using microarray. Expression profiling by microarray of Treg cells treated with DMSO or CBP inhibitor, and Th0 cells
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-66596 | biostudies-arrayexpress
GenomicsTargeting CREBBP/EP300 bromodomains in cancer
Targeting CREBBP/EP300 bromodomains in cancer
PRJNA433209 | ENA
ProteomicsEP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer
Ferroptosis is a form of regulated cell death characterized by oxidative injury-induced lipid peroxidation. However, the detailed protein post-translational modification regulatory mechanism of ferroptosis remains largely unknown. Here, we report that E1A binding protein P300 (EP300) acetyltransfera...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039998 | Pride
Human Cell Ip-ms Pdac 
GenomicsEffect of Ep300 silencing on gene expression of RAW264.7
Effect of Ep300 silencing on gene expression of RAW264.7
PRJNA1041384 | ENA
UnknownExperimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation.
Not available
S-EPMC9843983 | biostudies-literature
TranscriptomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71911 | biostudies-arrayexpress
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