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MetabolomicsDifferential interactions of dietary EPA and DHA with the gut microbiota dictate distinct metabolic outcomes in the host

Background: Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to modulate host physiology, but their differential interactions with the gut microbiota and consequent host metabolic effects remain poorly understood.

Methods: We employed shotgun metagenomics, untargeted met...

2026-01-31 | MTBLS13495 | MetaboLights
MetabolomicsDifferential interactions of dietary EPA and DHA with the gut microbiota dictate distinct metabolic outcomes in the host

Background: Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to modulate host physiology, but their differential interactions with the gut microbiota and consequent host metabolic effects remain poorly understood.

Methods: We employed shotgun metagenomics, untargeted met...

2026-01-31 | MTBLS13497 | MetaboLights
TranscriptomicsGene expression in colorectal liver metastasis tissues from EPA-treated patients
Eicosapentaenoic acid in its free fatty acid form (EPA-FFA), 2g daily, is safe and well-tolerated in patients undergoing liver resection surgery for colorectal liver metastasis.Oral EPA incorporates into colorectal liver metastasis tissue. EPA-FFA treatment is associated with reduced vascularity of ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-79266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HL60 cells treated with eicosapantaenoic acid (EPA) to investigate the effect on the signalling pathways involved in growth arrest/apoptosis
We investigated the effect of EPA on the signalling pathways involved in growth arrest/apoptosis in HL60 cells. EPA inhibited cell proliferation in HL60 cells in a dose dependent manner. Gene expression profiling of HL60 cells treated with EPA was performed by Affymetrix GeneChip. System and key mar...
ORGANISM(S): Homo sapiens 
2008-11-11 | E-MEXP-1389 | biostudies-arrayexpress
TranscriptomicsEffect of treatment OPM2 multiple myeloma cells with EPA, DHA or bortezomib
OPM2 cells were seeded in a 12-well plate at density of 10 × 103 cells/well and incubated with the indicated concentrations of compounds. OPM2 cells were treated with 50 µM of DHA/EPA (6 h) or 10 nM of bortezomib (4 h). Total RNA was extracted from cells using RNeasy Mini Kit (74104, Qiagen, Hilden,...
ORGANISM(S): Homo sapiens 
2022-06-26 | E-MTAB-11907 | biostudies-arrayexpress
TranscriptomicsEicosapentaenoic acid improves metabolic switching in human myotubes
Metabolically healthy skeletal muscle is characterized by the ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR ligand T0901317 a...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18589 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Il10-/- mutants treated with dietary eicosapentaenoic acid (EPA) to investigate intestinal inflammation
Dietary n-3 polyunsaturated fatty acids can reduce inflammation via a range of mechanisms. This study tested the effect of dietary eicosapentaenoic acid (EPA) on intestinal inflammation using interleukin-10 gene-deficient (Il10-/-) mice. Methods: At 35 days of age, 12 weaned Il10-/- and 12 C57 mice ...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-12028 | biostudies-arrayexpress
GenomicsComparison of gene expression in EPA sensitive and EPA resistant mouse colorectal cancer cells
Comparison of gene expression in EPA sensitive and EPA resistant mouse colorectal cancer cells
PRJNA557497 | ENA
UnknownAn assessment of important SPECIATE profiles in the EPA emissions modeling platform and current data gaps.
Not available
S-EPMC7252573 | biostudies-literature
TranscriptomicsFish oil supplementation induces anti-atherogenic gene expression profiles in human blood mononuclear cells
Fish oil supplementation is generally seen as beneficial for human health, due to the presence of n-3 polyunsaturated fatty acids (n-3 PUFAs). These fatty acids can elicit their effect through changes in gene expression. Effects of n-3 PUFAs on gene expression of inflammatory and atherogenic markers...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-12375 | biostudies-arrayexpress
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