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MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
ProteomicsSite-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags
Protein kinases are prime targets for drug development due to their involvement in various cancers. However, selective inhibition of kinases, while avoiding off-target effects remains a significant challenge for the development of protein kinase inhibitors. Activity-based protein profiling (ABPP), i...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058749 | Pride
Chemical proteomics  activity-based protein profiling  site-specific  protein kinase inhibitor profiling  ephrin receptor inhibitor  nvp-bhg712 
ProteomicsSingle methyl group positioning opens new chemical space for EPH receptor kinase inhibition
EPHrin receptors (EPH) are transmembrane receptor tyrosine kinases. Their extracellular domains bind specifically to ephrin A/B ligands, and this binding modulates the intracellular kinase activity. EPHs are key players in bidirectional intercellular signalling, controlling cell morphology, adhesion...
ORGANISM(S): Homo sapiens (Human) 
2018-09-05 | PXD009188 | Pride
Eph receptor Selectivity profiling Kinase inhibitor Kinobeads 
TranscriptomicsGene expression profiling in post mortem brain samples of patients with cirrhosis with and without hepatic encephalopathy
The study aimed at the identification of gene expression changes in brain of cirrhotic patients without or with HE as compared to controls. Tissue was taken from the fusiform gyrus. The dataset comprises 12 brain tissue samples divided into three sample groups each representing a certain liver dise...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-57193 | biostudies-arrayexpress
GenomicsIdentification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [snRNA-seq]
Identification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [snRNA-seq]
PRJNA1141979 | ENA
UnknownMuscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling.
Not available
S-EPMC8321669 | biostudies-literature
GenomicsIdentification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [RNA-seq]
Identification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [RNA-seq]
PRJNA846711 | ENA
UnknownThe Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models.
Not available
S-EPMC6468443 | biostudies-literature
OtherChemical proteomics uncovers EPHA2 as a mechanism of acquired resistance to small molecule EGFR kinase inhibition.
Data from ProteomeXchange, PXD ID: PXD001333. File: 000249_D01_P001442_B00_A00_R1.mzml. Published as part of J Proteome Res. 2015 May 12 . From the Abstract: {{i}} ... Here, we describe a chemical proteomic approach comprising kinase affinity purification (kinobeads) and quantitative mass spectrome...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310019962 | GPMDB
Resource Reanalysis 
UnknownBinding of the Kaposi's sarcoma-associated herpesvirus to the ephrin binding surface of the EphA2 receptor and its inhibition by a small molecule.
Not available
S-EPMC4136269 | biostudies-literature
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