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GenomicsHistone modification analysis in TGFbeta/TNFalpha treated A549 spheroid cultures
We studied the extent of chromatin remodeling in an in-vitro model of the epithelial-mesenchymal transition (EMT). EMT is induced in spheroid cultures (3D) using simultaneously two cytokines: TGFbeta and TNFalpha. The epithelial-mesenchymal transition (EMT) is a cellular de-differentiation process t...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-42374 | biostudies-arrayexpress
TranscriptomicsDownregulation of CK2-Beta is sufficient to drive epithelial-to-mesenchymal transition through Snail 1 induction
To understand how CK2M-NM-2 silencing promotes a mesenchymal phenotype in human epithelial cells, like TGFM-NM-2 does, we have employed whole genome microarray expression profiling as a discovery platform to compare genes regulated in CK2M-NM-2-depleted cells and in TGFM-NM-2-treated cells. To do s...
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-28569 | biostudies-arrayexpress
TranscriptomicsComparison of two hepatocellular cancer cell lines with distinct properties regarding epithelial-mesenchymal transition
The epithelial to mesenchymal transition (EMT) of malignant hepatocytes is a crucial event in hepatocellular carcinoma (HCC) progression and recurrence. We aimed to establish a human model of EMT to examine drug efficacy and specificity in HCC progression. Human HCC cell populations were characteriz...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26391 | biostudies-arrayexpress
MetabolomicsDynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) gro...

2022-12-08 | MTBLS5615 | MetaboLights
TranscriptomicsTranscription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1.
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic progression. Ionizing radiation (IR), both a carcinogen and a therapeutic agent, induces TGFbeta activation in vivo. We now show that I...
ORGANISM(S): Homo sapiens 
2008-11-08 | E-GEOD-8240 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of of Smad2 and Smad3 in mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Effects of Smad3 and Smad2 knock-down on TGFbeta-induced epithelial-to-mesenchymal transition (EMT) in mouse mammary epithelial (Nme) cells
ORGANISM(S): Mus musculus 
2009-04-01 | E-MEXP-1342 | biostudies-arrayexpress
TranscriptomicsCancer stem cell features shift during skin squamous cell carcinoma progression
Cancer stem cells (CSCs) play a key role in tumour growth and metastasis. Although an expansion of CSC population was previously described in advanced cutaneous squamous cell carcinoma (SCC), it remains unknown whether CSC regulatory mechanisms also change through tumour progression to promote malig...
ORGANISM(S): Mus musculus 
2016-01-08 | E-GEOD-59439 | biostudies-arrayexpress
ProteomicsDisturbed Balance of Protein Phosphatase Type 2A (PP2A) is Driving Epithelial-to-Mesenchymal Transition in Human Pan-creatic Cancer Patients
The incidence for pancreatic ductal adenocarcinoma (PDAC) is rising which has a low survival rate. In cancer, Epithelial-to-Mesenchymal transition (EMT) contribute to an aggressive phenotype. Protein Phosphatase Type 2A (PP2A) are initially regarded as tumor suppressors, the connection with EMT in p...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037976 | Pride
Pancreatic cancer  epithelial-to-mesenchymal progression  protein phosphatases type 2a  gene expression  proteomics  in vivo results  drug target 
GenomicsThe role of LSD1 in Epithelial to Mesenchymal Transition
The role of LSD1 in Epithelial to Mesenchymal Transition
PRJNA413779 | ENA
GenomicsTherapeutic induction of mesenchymal-epithelial transition via epigenetic reprogramming curtails metastatic progression and sensitizes breast cancers to treatment [ATAC-seq]
Therapeutic induction of mesenchymal-epithelial transition via epigenetic reprogramming curtails metastatic progression and sensitizes breast cancers to treatment [ATAC-seq]
PRJNA857041 | ENA
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