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ProteomicsMapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays
Here, we developed immunoprecipitation-mass spectrometry assays for the measurement of a low-abundance T1E4 TMPRSS2-ERG fusion protein, its isoforms and its interactome in VCaP prostate cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD021236 | Pride
Tmprss2-erg fusion  vcap cells  erg protein isoforms  proteomics  mass spectrometry  selected reaction monitoring  erg interactome  cbaf complex  canonical swi/snf complex 
GenomicsAn AR-ERG co-mediated chromatin interactome defines the transcriptional network in prostate cancer cells
An aberrant androgen receptor (AR) transcriptional network underpins prostate cancer development. Even though the AR cistrome had been extensively studied in prostate cancers, information pertaining to the spatial architecture of the AR transcriptional circuitry remains limited due to the absence of...
ORGANISM(S): Homo sapiens 
2018-12-14 | GSE54946 | GEO
UnknownMapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays.
Not available
S-EPMC8102805 | biostudies-literature
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
GenomicsHomo sapiens
An AR-ERG co-mediated chromatin interactome defines the transcriptional network in prostate cancer cells
PRJNA238129 | ENA
UnknownAn AR-ERG transcriptional signature defined by long-range chromatin interactomes in prostate cancer cells.
Not available
S-EPMC6360806 | biostudies-literature
UnknownALDH3A2, ODF2, QSOX2, and MicroRNA-503-5p Expression to Forecast Recurrence in TMPRSS2-ERG-Positive Prostate Cancer.
Not available
S-EPMC9569942 | biostudies-literature
TranscriptomicsT cell Activation is Regulated by Assembly of an RNA-binding Interactome Centered on the U2AF Heterodimer that Includes ILF2, SRRM2, and SYNCRIP [RIP-seq]
T cell activation leads to dramatic changes in cellular phenotype. We used CD3/CD28-activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show at the global level that U2AF2 binds the maj...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-62919 | biostudies-arrayexpress
TranscriptomicsT cell Activation is Regulated by Assembly of an RNA-binding Interactome Centered on the U2AF Heterodimer that Includes ILF2, SRRM2, and SYNCRIP [RNA-seq]
T cell activation leads to dramatic changes in cellular phenotype. We used CD3/CD28-activated human CD4 T cells to study how RNA binding proteins define the post-transcriptional landscape. Using RIPseq, we identified the RNA interactome of U2AF2 and show at the global level that U2AF2 binds the maj...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-62920 | biostudies-arrayexpress
TranscriptomicsCross-species analysis of genome-wide regulatory networks identifies a synergistic dependency between FOXM1 and CENPF that drives prostate cancer malignancy
Analysis of the transcriptome of mouse models of prostate cancer to assemble a mouse prostate cancer interactome. To assemble the mouse prostate cancer interactome, we collected 13 distinct mice or genetically-engineered mouse models (GEMMs), which together represent the full spectrum of prostate ca...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-53202 | biostudies-arrayexpress
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