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ProteomicsMapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays
Here, we developed immunoprecipitation-mass spectrometry assays for the measurement of a low-abundance T1E4 TMPRSS2-ERG fusion protein, its isoforms and its interactome in VCaP prostate cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD021236 | Pride
Tmprss2-erg fusion  vcap cells  erg protein isoforms  proteomics  mass spectrometry  selected reaction monitoring  erg interactome  cbaf complex  canonical swi/snf complex 
TranscriptomicsExpression data from transgenic ERG, GATA1s KI and ERG/GATA1s fetal livers
DS children have a 500-fold increased risk for developing acute megakaryoblastic leukemia (AMKL). Around 10% of DS newborns have a transient myeloproliferative disorder (TMD) that resolves spontaneously. Somatic mutations acquired during fetal hematopoiesis in the GATA1 transcription factor are dete...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-46481 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel isoforms of Huntingtin reveals a new hominid-specific exon
Huntington’s disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT is an evolutionarily conserved and ubiquitously expressed protein that has been linked to a variety of functions including transcriptional r...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-66769 | biostudies-arrayexpress
UnknownSequence-function correlations and dynamics of ERG isoforms. ERG8 is the black sheep of the family.
Not available
S-EPMC4716293 | biostudies-literature
TranscriptomicsDifferential roles of Sall4 isoforms in ES cell pluripotency
This SuperSeries is composed of the following subset Series: GSE21054: Differential roles of Sall4 isoforms in ES cell pluripotency: expression GSE21055: Differential Role of Sall4 isoforms in ES cell pluripotency: ChIP-chip Refer to individual Series
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-21056 | biostudies-arrayexpress
TranscriptomicsAllele-selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-coding and Noncoding RNAs, and RNA Isoforms
Purpose: mRNA translation into protein is highly regulated, but the role of mRNA isoforms, noncoding RNAs (ncRNAs), and genetic variants has yet to be systematically studied. Using high-throughput sequencing (RNA-seq), we have measured cellular levels of mRNAs and ncRNAs, and their isoforms, in lym...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-66135 | biostudies-arrayexpress
UnknownAntibody-independent targeted quantification of TMPRSS2-ERG fusion protein products in prostate cancer.
Not available
S-EPMC4183720 | biostudies-literature
UnknownMapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays.
Not available
S-EPMC8102805 | biostudies-literature
GenomicsDeregulation of DUX4 and ERG in acute lymphoblastic leukemia
Chromosomal rearrangements deregulating hematopoietic transcription factors are common leukemia-initiating lesions in acute lymphoblastic leukemia (ALL). Here, we show that deregulation of the homeobox transcription factor gene DUX4 and the ETS transcription factor gene ERG are hallmarks of a subtyp...
EGAS00001001923 | EGA
UnknownMicro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer.
Not available
S-EPMC10355945 | biostudies-literature
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