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ProteomicsImmunocompatible Elastomer with increased resistance to the foreign body response
Polymeric elastomers are extensively employed to fabricate implants intended for prolonged implantation. However, implantation of the elastomers can induce strong immune rejection reaction known as foreign body response (FBR), resulting in the rejection of foreign implants and thereby diminishing th...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD054629 | Pride
Foreign body response 
TranscriptomicsRNA-seq of mouse sciatic peripheral nerve of uninjured mouse against implantation of a silicon device or peripheral nerve injury.
Foreign body reaction is one of the most important limiting factors to the clinical translation of implantable bioelectronics. The experiment compares the process of foreign body reaction, following the implantation of a silicon device in a mouse peripheral nerve, to that of peripheral nerve injury,...
ORGANISM(S): Mus musculus 
2022-04-30 | E-MTAB-10294 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse sciatic peripheral nerve of injured mouse with implant: control (untreated) vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex). .
RNA-seq comparing expression profile of peripheral nerve damage and microchannel device implantation repair model: control vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex).
ORGANISM(S): Mus musculus 
2022-04-30 | E-MTAB-10293 | biostudies-arrayexpress
GenomicsOsteopontin Reduces Foreign Body Response in Silicone-Based Implants in Humans and Mice
Osteopontin Reduces Foreign Body Response in Silicone-Based Implants in Humans and Mice
PRJNA1171733 | ENA
GenomicsImmunocompatible Elastomer with increased resistance to the foreign body response
Immunocompatible Elastomer with increased resistance to the foreign body response
PRJNA1148948 | ENA
GenomicsRole of Macrophages in the Foreign Body Response to Poly(ethylene glycol) Hydrogels
Role of Macrophages in the Foreign Body Response to Poly(ethylene glycol) Hydrogels
PRJNA770680 | ENA
TranscriptomicsOsteopontin Reduces Foreign Body Response in Silicone-Based Implants in Humans and Mice
Subcutaneous implants often elicit an inflammatory foreign body response (FBR) in the shape of a capsule around the implanted material, and it is not yet clear why certain materials such as dermal matrix (ADM), clinically used in breast reconstruction, are more efficient in attenuating this chronic ...
ORGANISM(S): Homo sapiens Mus musculus 
2025-03-01 | GSE279258 | GEO
TranscriptomicsImmunocompatible Elastomer with increased resistance to the foreign body response
Polymeric elastomers are extensively employed to fabricate implants intended for prolonged implantation. However, implantation of the elastomers can induce strong immune rejection reaction known as foreign body response (FBR), resulting in the rejection of foreign implants and thereby diminishing th...
ORGANISM(S): Mus musculus 
2024-08-17 | GSE275010 | GEO
UnknownUnderstanding the Foreign Body Response via Single-Cell Meta-Analysis.
Not available
S-EPMC11273435 | biostudies-literature
UnknownImmunometabolic Approaches Mitigating Foreign Body Response and Transcriptome Characterization of the Foreign Body Capsule.
Not available
S-EPMC11828940 | biostudies-literature
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