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MetabolomicsSerum untargeted metabolomics reveals distinct metabolic signatures and potential biomarkers in female and latent genital tuberculosis

Female genital tuberculosis (FGTB) and latent genital tuberculosis (LGTB) critically impair women's reproductive health. However, their early diagnosis and treatment remain challenging due to nonspecific symptoms and suboptimal diagnostic methods. This study utilized serum untargeted metabolomics...

2025-12-25 | MTBLS12319 | MetaboLights
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
TranscriptomicsTargeted disruption of BMAL1 in the peripheral reproductive axis results in infertility in female mice
The product of the Bmal1 locus is an essential component of the circadian clock that plays important roles in various aspects of reproductive biology,and when disrupted results in infertility. In an effort to establish the identity of the tissue specific clock that is responsible for this infertilit...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-48758 | biostudies-arrayexpress
TranscriptomicsRNA-seq from oocytes and zygotes of pabpn1l ko and wt female mice during different stages
PABPN1L participates in the process of post-transcriptional regulation and degradation of maternal mRNA.So,we collect samples of each period from pabpn1l ko and wt female mice during different stages.Then, RNA was extracted and detected.Reverse transcription was performed on the samples that met the...
ORGANISM(S): Mus musculus 
2021-03-19 | E-MTAB-10199 | biostudies-arrayexpress
GenomicsGenetic Variants in Pakistani families with female infertility
Genetic Variants in Pakistani families with female infertility
PRJEB111034 | ENA
TranscriptomicsIdentification of genes associated with pistil development by transcriptome analysis of a female sterility mutant (fsm) in Chinese cabbage (Brassica campestris ssp. pekinensis)
The female sterility mutants are ideal materials for studying the pistil development in plants. We identified a female sterility mutant (fsm) exhibiting stable inheritance, which was derived from a Chinese cabbage DH line ‘FT’ using the combination of isolated microspore culture and ethyl methan...
ORGANISM(S): Brassica rapa subsp. pekinensis 
2016-06-02 | E-GEOD-76917 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Foxo3 mutant ovaries vs. wild types to discover and classify ovarian fertility factors.
Female infertility syndromes are among the most prevalent chronic health disorders in women, but their molecular basis remains unknown because of the complexity of oogenesis and uncertainty regarding the number and identity of ovarian factors controlling the assembly, preservation, and maturation of...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8249 | biostudies-arrayexpress
ProteomicsDeficiency of OGT-mediated O-GlcNAcylation causes female infertility with oocyte meiotic arrest and follicle development defects by impairing mitochondrial function
Abnormalities in oocyte meiosis are a major cause of female infertility. Since transcriptional activity is largely absent during oocyte meiosis, post-translational modifications of proteins play an essential regulatory role. Among these, OGT-mediated O-GlcNAcylation is a key modification involved in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-31 | PXD071809 | Pride
Ogt  o-glcnacylation  female infertility  oocyte  mitochondrial function 
ProteomicsDeficiency of OGT-mediated O-GlcNAcylation causes female infertility with oocyte meiotic arrest and follicle development defects by impairing mitochondrial function
Abnormalities in oocyte meiosis are a major cause of female infertility. Since transcriptional activity is largely absent during oocyte meiosis, post-translational modifications of proteins play an essential regulatory role. Among these, OGT-mediated O-GlcNAcylation is a key modification involved in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-31 | PXD071865 | Pride
Ogt  o-glcnacylation  female infertility  oocyte  mitochondrial function 
GenomicsFemale Infertility: Primary Ovarian Insufficiency
Female Infertility: Primary Ovarian Insufficiency
PRJNA330891 | ENA
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