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MetabolomicsSerum untargeted metabolomics reveals distinct metabolic signatures and potential biomarkers in female and latent genital tuberculosis

Female genital tuberculosis (FGTB) and latent genital tuberculosis (LGTB) critically impair women's reproductive health. However, their early diagnosis and treatment remain challenging due to nonspecific symptoms and suboptimal diagnostic methods. This study utilized serum untargeted metabolomics...

2025-12-25 | MTBLS12319 | MetaboLights
TranscriptomicsExpression data from female reproductive organs of adult mice treated with estrogen
Estrogen induce organ-specific cell proliferation and development in female reproductive organs, though the reproductive differentiation, sex maturation, implantation and lactation. However, the mechanism of organ-specific estrogen responsive genes is unknown. Thus, we examined early estrogen respon...
ORGANISM(S): Mus musculus 
2007-02-06 | E-GEOD-6931 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish ovary treated with the reproductive toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
2,3,7,8-TCDD (TCDD) is a reproductive toxicant and endocrine disruptor in nearly all vertebrates, yet the mechanisms by which TCDD induces these reproductive alterations have not been fully characterized. Fish are among the most sensitive vertebrates to the toxic effects of TCDD, and even subtle ph...
ORGANISM(S): Danio rerio 
2009-04-30 | E-GEOD-4859 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila mated females to identify mating response genes
Male-derived accessory gland proteins (Acps) that are transferred to females during mating have profound effects on female reproductive physiology including increased ovulation, mating inhibition, and effects on sperm utilization and storage. The extreme rates of evolution seen in Acps may be driven...
ORGANISM(S): Drosophila melanogaster 
2008-06-13 | E-GEOD-5012 | biostudies-arrayexpress
GenomicsAsynchronous female reproductive organ ageing as revealed by single-cell transcriptomic atlas
Asynchronous female reproductive organ ageing as revealed by single-cell transcriptomic atlas
PRJNA1007677 | ENA
MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
TranscriptomicsTranscription profiling by array of mouse oviduct, uterus and vagina treated with DES from new born mice to understand the mechanism of the differentiation of female reproductive tracts
Diethylstilbestrol (DES) inhibits the differentiation of female reproductive tracts during fetal and neonatal days . We examined global gene expressions in the oviduct, uterus and vagina in newborn mice with or without DES. These results suggest understanding the mechanism of the differentiation of...
ORGANISM(S): Mus musculus 
2004-10-28 | E-GEOD-1886 | biostudies-arrayexpress
ProteomicsMucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human endo- and ecto-cervix chips
Modulation of mucus production by the human ecto- and endo-cervical epithelium by steroid hormones and associated interactions with commensal microbiome play a central role in the physiology and pathophysiology of the female reproductive tract. However, most of our knowledge about these interactions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-26 | MSV000091806 | MassIVE
TranscriptomicsTranscription profiling of rat ovary in culture reveals interactions between progesterone and tumor necrosis factor-alpha in the regulation of primordial follicle assembly
Follicle assembly is the process by which groups or ‘nests’ of oocytes break down to form primordial follicles. The size of the primordial follicle pool is the major determinant of the reproductive lifespan of a female. Previously, progesterone (P4) has been shown to inhibit follicle assembly,...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8238 | biostudies-arrayexpress
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