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TranscriptomicsThe effect of fenofibrate on endothelial cells
Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we ge...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-15483 | biostudies-arrayexpress
TranscriptomicsHuman umbilical vein endothelial cells (HUVECs) treated with fenofibrate
This SuperSeries is composed of the following subset Series: GSE15482: The effect of PPARa siRNA on endothelial cells treated with fenofibrate GSE15483: The effect of fenofibrate on endothelial cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-08-24 | E-GEOD-15494 | biostudies-arrayexpress
TranscriptomicsThe effect of PPARa siRNA on endothelial cells treated with fenofibrate
Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we ge...
ORGANISM(S): Homo sapiens 
2009-08-24 | E-GEOD-15482 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomics and metabolomic analysis of fenofibrate and fish oil treatments in mice
Elevated circulating triglycerides, which are considered a risk factor for cardiovascular disease, can be targeted by treatment with fenofibrate or fish oil. To gain insight into underlying mechanisms, we carried out a comparative transcriptomics and metabolomics analysis of the effect of 2 week tre...
ORGANISM(S): Mus musculus 
2011-10-07 | E-GEOD-32706 | biostudies-arrayexpress
TranscriptomicsChanges of the gene expression profiling induced by fenofibrate
To make investigation of the apoptosis-inducing effect of fenofibrate, the Gene expression profile chip was used to compare the changes between the control group (0M-NM-
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-49965 | biostudies-arrayexpress
TranscriptomicsFenofibrate increases VLDL-triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
The PPAR? activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced VLDL-TG clearance and decreased VLDL-TG production. However, since data on the effect of fenofibrate on VLDL production are controversial, we aimed to investigate in (more) deta...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21211 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate
Fenofibrate is a specific agonist of the nuclear receptor PPARa. To identify the gene expression under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara ...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73298 | biostudies-arrayexpress
TranscriptomicsMuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.
MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy Four strain-matched groups of 3-8 week old mice were investigated: 1) MuRF1 -/- Fenofibrate feed; 2) MuRF1 -/- chow feed; 3) MuRF1 +/+ Fenofibrate feed; 4) MuRF1 +/+ chow feed at...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-68480 | biostudies-arrayexpress
TranscriptomicsLinalool, an aromatic terpenoid, rewires transcriptome profile of lipid-loaded HepG2 cells
The microarray results showed that linalool sitimulation of lipid-loaded HepG2 cells rewired the hepatic transcriptome profile, with linalool being comparable to those of fenofibrate. Total of 8,988 genes that were commonly and significantly expressed in all experimental groups, including control he...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-45961 | biostudies-arrayexpress
TranscriptomicsAldr KO mice in liver with Fenofibrate treatment
Transcriptomic characterization of ABCD2 KO mice to fibrate treatment in liver tissue, 3 months of age ABCD2 KO and age-matched WT mice were administered fenofibrate (100 mg/kg/day) for 14 days.
ORGANISM(S): Mus musculus 
2014-04-01 | E-MTAB-2006 | biostudies-arrayexpress
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