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MetabolomicsAnalyze the metabolic characteristics in fecal and peripheral blood plasma samples from different patient populations_blood

Given that hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC) exhibits unique gut microbial and metabolic characteristics that influence the immunosuppressive tumor microenvironment, a better understanding of the correlations among gut microbiota, metabolism, and immunosuppressive...

2025-10-29 | MTBLS13231 | MetaboLights
GenomicsThe DNA methylome of human peripheral blood mononuclear cells
DNA methylation plays a vital role in genome dynamics and, in the human genome, occurs predominantly at cytosine guanine dinucleotide (CpG) sites. The diploid haploid human genome analysed here contains around 2060 million CpG sites (methylome) where DNA methylation can vary, affecting many biologic...
ORGANISM(S): Homo sapiens 
2010-09-04 | E-GEOD-17972 | biostudies-arrayexpress
TranscriptomicsFetal transcripts in maternal blood
The discovery of fetal mRNA transcripts in maternal circulation holds great promise for noninvasive prenatal diagnosis. To identify potential fetal biomarkers, we studied whole blood and plasma transcripts common to term pregnant women and their newborns but reduced or absent in the postpartum mothe...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53669 | biostudies-arrayexpress
TranscriptomicsComparison of CD8+ memory T-cells from fresh and high density precultured PBMC.
High density cultured CD8+ memory T-cells from peripheral blood mononuclear cells (PBMC) were found to be more sensitive towards antigenic stimulation. We used microarrays to detail the global programme of gene expression underlying differences in the cell density of human PBMC and identified genes ...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-63430 | biostudies-arrayexpress
ProteomicsFlow Cytometry Analysis of Circulating Extracellular Vesicle Subtypes from Fresh Body Fluids
Extracellular vesicles (EVs) are released by shedding during different physiological processes and are increasingly thought to be new potential biomarkers. However, the impact of pre-analytical processing phases on the final measurement is not predictable and, for this reason, the translation of bas...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD022807 | Pride
Extracellular vesicles  polychromatic flow cytometry  biomarkers  proteomics  fresh peripheral blood. 
ProteomicsThe Impact of Blood-Processing Time on the Proteome of Human Peripheral Blood Mononuclear Cells
Human peripheral blood mononuclear cells (PBMC) are key to several diagnostics assays and basic science research. Blood pre-analytical variations that occur before obtaining the PBMC fraction can have a significant impact on the results of the assays, including viability, composition, integrity, and...
ORGANISM(S): Homo sapiens (Human) 
2020-12-14 | PXD021367 | Pride
Pbmc Immunology. Proteomics Itraq Blood 
TranscriptomicsProfiling of peripheral blood mononuclear cells from HIV-1-infected elite suppressors, viremic patients, and uninfected control donors
This SuperSeries is composed of the following subset Series: GSE33387: NanoString miRNA profiling of peripheral blood mononuclear cells from HIV-1-infected elite suppressors, viremic patients, and uninfected control donors GSE33492: TaqMan Peripheral blood mononuclear cell miRNA profiles of HIV-1-in...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-33617 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the effect of cryopreservation on peripheral blood mononuclear cells
Analysis of cryopreservation effects on peripheral blood mononuclear cells at gene expression level. The hypothesis tested in the present study was that cryopreservation has an influence on the transcriptome profile of peripheral blood mononuclear cells. Results indicated remarkable changes in expre...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-24753 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.
Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, a...
ORGANISM(S): Homo sapiens 
2010-09-16 | E-GEOD-24147 | biostudies-arrayexpress
TranscriptomicsExpression data from peripheral blood mononuclear cells of subjects supplemented with vitamin C
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54477 | biostudies-arrayexpress
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