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GenomicsFrancisella tularensis subsp. holarctica FSC200
Francisella tularensis subsp. holarctica FSC200 hybrid sequencing
PRJNA510899 | ENA
ProteomicsIdentification of immunoreactive proteins in murine sera after immunization with outer membrane vesicles isolated from Francisella tularensis subsp. holarctica strain FSC200
Secretion of outer membrane vesicles (OMV) presents an important phenomenon in Gram-negative bacteria and they play multiple roles in their lifestyle including virulence and host-pathogen interaction. Francisella tularensis secretes unusually shaped tubular OMV filled with immunoreactive material an...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 
2024-02-22 | PXD047830 | Pride
Francisella tularensis  fsc200  outer membrane vesicles  immunoreactive  host-pathogen interaction  vaccination  western blot  2d sds-page 
ProteomicsProteomic characterization and label-free comparison of outer membrane vesicles from Francisella tularensis subsp. holarctica strain FSC200 isolated from different cultivation conditions
Francisella tularensis is a Gram-negative, facultative intracellular bacterium, causing a severe disease known as tularemia. It is known to secrete unusually shaped nanotubular outer membrane vesicles (OMV) loaded with number of virulence factors and immunoreactive proteins. In this study the nanotu...
ORGANISM(S): Francisella tularensis subsp. holarctica Francisella tularensis subsp. holarctica FSC200 
2019-09-30 | PXD013074 | Pride
Francisella tularensis  fsc200  outer membrane vesicles  stress response 
GenomicsFrancisella tularensis subsp. holarctica FSC200
Causative agent of tularemia
PRJNA16087 | ENA
ProteomicsFrancisella tularensis DsbA mutant MS/SILAC analysis
Comparison of enriched membrane fractions of Francisella tularensis subsp. holarctica strain FSC200 and its DsbA mutant by SILAC analysis.
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 
2018-01-15 | PXD007682 | Pride
Q-exactive Silac Francisella tularensis 
UnknownArginine 58 is indispensable for proper function of the Francisella tularensis subsp. holarctica FSC200 HU protein, and its substitution alters virulence and mediates immunity against wild-type strain.
Not available
S-EPMC9578482 | biostudies-literature
ProteomicsCross-species proteomic comparison of whole cell lysates, outer membrane vesicles and membrane fractions of Francisella tularensis subsp. tularensis versus subsp. holarctica
Secretion of outer membrane vesicles (OMV) presents an important phenomenon in Gram-negative bacteria and they play multiple roles in their lifestyle including virulence and host-pathogen interaction. Francisella tularensis secretes unusually shaped tubular OMV. We here present a proteomic compariso...
ORGANISM(S): Francisella tularensis Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. holarctica FSC200 
2021-02-08 | PXD022406 | Pride
Q-exactive Schus4 Outer membrane vesicles Fsc200 Cross-species proteomic comparison Francisella tularensis 
ProteomicsThe identification of bacterial protein interaction partners pointed out to new intracellular functions of Francisella tularensis glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phopshate dehydrogenase (GAPDH) is well-known for its involvement in numerous non-metabolic processes inside the mammalian cells. Alternative functions of prokaryotic GAPDH are mainly deduced from its extracellular localization and the ability to bind to selected host proteins. Data...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 Bacteria 
2020-08-31 | PXD019739 | Pride
Interaction partners Francisella tularensis 
UnknownA ΔclpB mutant of Francisella tularensis subspecies holarctica strain, FSC200, is a more effective live vaccine than F. tularensis LVS in a mouse respiratory challenge model of tularemia.
Not available
S-EPMC3827231 | biostudies-literature
ProteomicsPleiotropic effect of Francisella ABC transporter gene inactivation on production of glycoconjugates
The present study deals with the cross-talk of polysaccharide biosynthesis pathways of a highly infectious intracellular pathogen Francisella tularensis, the causative agent of tularemia. We have studied the consequences of disrupting the FTS_1402 gene that lies within the putative polysaccharide lo...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 
2016-02-04 | PXD002123 | Pride
Glycosylation Q-exactive Francisella 
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