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ProteomicsKSN01_Proteome_CellLine: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
ORGANISM(S): Homo Sapiens (human) 
2020-12-15 | PXD010107 | JPOST Repository
TranscriptomicsThe gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome
Recently, expression profiling of breast carcinomas has revealed gene signatures that predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. Measurement of the degree of genomic instability provides a very similar stratification of prognostic groups. We therefore...
ORGANISM(S): Homo sapiens 
2009-11-30 | E-GEOD-11901 | biostudies-arrayexpress
TranscriptomicsHuman ES cells reveal recurrent genomic instability at 20q11.21
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we detected a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing about 23 genes in common, appeared in four cell lines of different origins. This amplification, ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-13565 | biostudies-arrayexpress
GenomicsLoss of histone demethylase JARID1C triggers genomic instability in cancer.
Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the genetic inactivation of JARID1C leads to cancer remains largely unknown. Here we report that JARID1C bin...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73267 | biostudies-arrayexpress
TranscriptomicsUpregulation of FOXM1 Induces Genomic Instability in Human Epidermal Keratinocytes
Genome-wide 10k SNP profiling of FOXM1B-transduced N/TERT and primary normal human epidermal keratinocytes (NHEK). The aim of this study was to study the cancer initiation role of UVB and FOXM1B upregulation in NHEK. Upregulation of FOXM1B alone (without UVB) was found to directly induce genomic ins...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-16937 | biostudies-arrayexpress
TranscriptomicsApplication of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions
Chromosomal instability is central to the process of carcinogenesis. The detection of somatic chromosomal alterations in small premalignant lesions genome-wide remains challenging since sample heterogeneity dilutes the aberrant cell information. We introduced an analytic metric termed "delta-θ&...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-43168 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for Genomic Instability and Myelodysplasia with Monosomy 7
Gene modified autologous hematopoietic stem cells (HSC) can provide significant clinical benefits to patients suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life threatening bacterial and fungal infections. Here we...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-19523 | biostudies-arrayexpress
TranscriptomicsA new classification of chromosome instability (CIN) phenotype, CIN-high and CIN-low
Samples were taken from colorectal cancers in surgically resected specimens in 35 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be u...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-30540 | biostudies-arrayexpress
UnknownDifferences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.
Not available
S-EPMC4417177 | biostudies-literature
TranscriptomicsHigh-resolution genetic analysis of cancer cell lines with near normal karyotypes
Cancer development is associated with multiple genetic alterations and genomic instability either at the chromosomal or base pair level is generally thought to underlie these changes. However, it is still unknown whether genetic instability is absolutely required for tumorigenesis. Here we investig...
ORGANISM(S): Homo sapiens 
2008-03-14 | E-GEOD-8649 | biostudies-arrayexpress
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