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TranscriptomicsGITR and GITRL protects non-epithelioid mesothelioma cells from radiation
GITR and GITRL overexpress in sarcomatoid mesotelioma cells than epithelioid subtype, and cisplatin or radiation results an increase of GITR and GITRL expression on tumor cells. After sorting CRL9546 cells into GITR+(R), GITRL+(L), and GITR-/GITRL- (DN) cell populations. Three cell subsets were labe...
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-10647 | biostudies-arrayexpress
TranscriptomicsmRNA expression in CD4+ CD25+ GITR+ regulatory T cells from WT and Bach2 KO mice
Bach2 regulates homeostasis of foxp3+ regulatory T cells and protects against fatal lung disease in mice. Cells from WT and Bach2 KO spleen were isolated. CD4+ CD25+ GITR+ (Treg) cells were sorted by FACS sorting. Total RNAs were extracted from sorted Treg cells using by Rneasy Kit (Qiagen).
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52337 | biostudies-arrayexpress
ProteomicsAnalysis of GITR and OX40 signaling complexes
T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-25 | PXD046422 | Pride
T cells  co-stimulation  gitr  ox40  abin1  ms 
UnknownLigand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry.
Not available
S-EPMC12823560 | biostudies-literature
UnknownAn anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Not available
S-EPMC8960412 | biostudies-literature
UnknownCD8+ T cells: GITR matters.
Not available
S-EPMC3361162 | biostudies-literature
UnknownOptimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
Not available
S-EPMC9245059 | biostudies-literature
UnknownPharmacological modulation of GITRL/GITR system: therapeutic perspectives.
Not available
S-EPMC3413846 | biostudies-literature
GenomicsTranscriptome profiling of ILC2 co-stimulated by GITR signaling under Activation condition
Transcriptome profiling of ILC2 co-stimulated by GITR signaling under Activation condition
PRJNA1252069 | ENA
ProteomicsFc-optimized GITR antibody enhances a CD4 T cell-dendritic cell crosstalk to promote anti-tumor immunity
Targeting the stimulatory immune checkpoint glucocorticoid-induced TNFR-related protein (GITR) using agonistic monoclonal antibodies (mAbs) is a promising strategy for cancer immunotherapy that activates effector T cells and eliminates regulatory T cells (Treg). The pre-clinical anti-tumor activity ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD077619 | Pride
Glycosylation Glycoproteomics Tumor Immunity 
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