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MetabolomicsSNAP25 inhibits glioma progression by regulating synapse plasticity via GLS-mediated glutaminolysis

INTRODUCTION: Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about syn...

2021-08-12 | MTBLS2806 | MetaboLights
TranscriptomicsTranscription profling of glioblastoma stem-like (GS) cell lines, conventional glioma cell lines and primary tumors
We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We us...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-23806 | biostudies-arrayexpress
TranscriptomicsIdentification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ
Gliomas are mostly incurable secondary to their diffuse infiltrative nature. Thus, specific therapeutic targeting of invasive glioma cells is an attractive concept. As cells exit the tumor mass and infiltrate brain parenchyma, they closely interact with a changing micro-environmental landscape that ...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-53717 | biostudies-arrayexpress
TranscriptomicsHuman glioma cells: Control (GFP) vs PDGF-A expressing
Transcriptional profiling of human glioma cells comparing control GFP expressing cells with glioma cells transfected with a human PDGF-A gene. The isogenic cell lines were used to study the impact on glioma tumorigenesis and invasion. Goal was to determine the effects of PDGF-A gene transfection on ...
ORGANISM(S): Homo sapiens 
2011-04-21 | E-GEOD-28748 | biostudies-arrayexpress
TranscriptomicsExpression data from normal brain/glioma associated macrophages
Tumor associated macrophages are contributing to local invasion, angiogensis, and metastasis during the progression of many kinds of tumor including glioma We used microrray to study the difference of expression of glioma associated macrophages and normal brain tissue associated macrophages The macr...
ORGANISM(S): Mus musculus 
2012-05-27 | E-GEOD-38283 | biostudies-arrayexpress
TranscriptomicsEffects of CBD on the glioma stem cell molecular signature
Primary glioma stem cells cultured as neurospheres in NBL media with growth factors were subjected to treatment with the non-toxic, non-psychoactive cannabis compound cannabidiol (CBD). Control and CBD- treated cultures were used to generate RNA used to hybridize on Affymetrix DNA arrays Fluorescenc...
ORGANISM(S): Homo sapiens 
2015-04-17 | E-GEOD-57978 | biostudies-arrayexpress
GenomicsIdentification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ
Identification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ
PRJNA232712 | ENA
TranscriptomicsEffects of silencing miR-10b in an U87-2M1 glioma line - an invasive in vivo derived subline of U87 glioma cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35208 | biostudies-arrayexpress
GenomicsCircGLIS3 promotes high-grade glioma invasion via modulating Ezrin phosphorylation
CircGLIS3 promotes high-grade glioma invasion via modulating Ezrin phosphorylation
PRJNA698359 | ENA
UnknownAdaptive adhesion systems mediate glioma cell invasion in complex environments.
Not available
S-EPMC6104823 | biostudies-literature
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