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Cancer cells frequently alter their lipids to grow and adapt to their environment1–3. Despite the critical functions of lipid metabolism in membrane physiology, signaling, and energy production, how specific lipids contribute to tumorigenesis is incompletely understood. Here, using functional genomi...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-26 | PXD052718 | Pride
Differentiation of epithelial cells is strongly affected by transcription factors related to epithelial to mesenchymal-like progression. We used gene expression profiling to identify genes that are differentially regulated upon repression of the transcription factor Zeb1 (deltaEF1/Areb6). NM18 cells...
ORGANISM(S): Mus musculus 
The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions
Glycosphingolipid synthesis mediates immune evasion in Kras-driven cancer
Gomesins (AgGom and HiGom) are therapeutically promising spider-derived peptides that target a specific phospholipid composition (3PC:1PS:1Chol) to disrupt melanoma cell membranes and induce cytotoxicity. Their antiproliferative properties are interrelated to lipid metabolism, particularly glycosphi...
ORGANISM(S): Homo sapiens 
2025-12-21 | GSE307218 | GEO
Isolation and characterization of two recently isolated Novosphingobium oxfordensis sp. nov. and Novosphingobium mississippiensis sp. nov. strains from soil, with LCMS and genome-based investigation of their glycosphingolipid productions
ORGANISM(S): Novosphingobium Mississippiensis Sp. Nov. Novosphingobium Oxfordensis Sp. Nov. 
2024-07-03 | MSV000095235 | MassIVE
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