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ProteomicsHepatic AKAP1 Deficiency Exacerbates Diet-Induced MASLD by Enhancing GPAT1-mediated Lysophosphatidic Acid Synthesis
Metabolic dysfunction-associated steatotic liver disease (MASLD), closely associated with obesity, can progress to metabolic dysfunction-associated steatohepatitis when the liver undergoes overt inflammatory damage. A-kinase anchoring protein 1 (AKAP1) has been shown to control lipid accumulation in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD062388 | Pride
Akap1  masld  lysophosphatidic acid  gpat1  triglyceride synthesis. 
UnknownFunctional Analysis of Genes Involved in Glycerolipids Biosynthesis (GPAT1 and GPAT2) in Pigs.
Not available
S-EPMC6617006 | biostudies-literature
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S-EPMC7829857 | biostudies-literature
UnknownHepatic AKAP1 deficiency exacerbates diet-induced MASLD by enhancing GPAT1-mediated lysophosphatidic acid synthesis.
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S-EPMC12062205 | biostudies-literature
Unknown6-Gingerol Ameliorates Hepatic Steatosis via HNF4α/miR-467b-3p/GPAT1 Cascade.
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S-EPMC8445893 | biostudies-literature
UnknownDual expression of plastidial GPAT1 and LPAT1 regulates triacylglycerol production and the fatty acid profile in Phaeodactylum tricornutum.
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S-EPMC6249879 | biostudies-literature
UnknownGlycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
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S-EPMC3277174 | biostudies-literature
UnknownGlycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation.
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S-EPMC4823928 | biostudies-literature
UnknownCloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2).
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S-EPMC2133398 | biostudies-literature
UnknownAralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.
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S-EPMC3868379 | biostudies-literature
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