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Improving gene set enrichment analysis (GSEA) by using regulation directionality
To infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene is activated or repressed by a regulator. This distinction...
ORGANISM(S): Bacillus subtilis 
2022-09-30 | GSE208571 | GEO
We investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. In vivo ad...
ORGANISM(S): Homo sapiens 
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