gspt1 - OmicsDI

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Department of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (1)
German Cancer Research Center, Division Proteomics of Stem Cells and Cancer, Heidelberg, Germany Heidelberg University, Medical Faculty, Heidelberg, Germany (1)
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Tags

xref:PubMed:33674273 (2)
xref:PubMed:40670672 (1)
xref:PubMed:35763353 (1)
xref:PubMed:41270153 (1)
xref:PubMed:33197925 (1)
xref:PubMed:41963303 (1)
xref:PubMed:34838332 (1)

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Potential of GSPT1 as a novel target for glioblastoma therapy.

Not available

S-EPMC11310507 | biostudies-literature

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

PRJNA1269060 | ENA

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders.

Not available

S-EPMC12713026 | biostudies-literature

High cereblon expression in neuroendocrine cancer confers vulnerability to GSPT1 molecular glue degrader.

Not available

S-EPMC12186427 | biostudies-literature

Degrade BTK and GSPT1 Proteins Concurrently

GBD-9 chemically induce the degradation of BTK and GSPT1 by merging the PROTAC and MG strategies.

ORGANISM(S): Homo Sapiens

PXD025609 |

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

IRAK4 is a therapeutic target in myeloid malignancies, but current IRAK4 inhibitors show only modest clinical efficacy in acute myeloid leukemia (1), highlighting the need for combination strategies. To identify drugs with synergistic potential alongside IRAK4 inhibitors, we conducted a high-through...

ORGANISM(S): Homo sapiens

2025-09-03 | GSE298391 | GEO

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells.

Not available

S-EPMC9374383 | biostudies-literature

PROTAC-Mediated GSPT1 Degradation Impairs the Expression of Fusion Genes in Acute Myeloid Leukemia.

Not available

S-EPMC11763475 | biostudies-literature

Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives.

Not available

S-EPMC10034078 | biostudies-literature

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization.